Two Different Approaches for Oral Administration of Voriconazole Loaded Formulations: Electrospun Fibers versus β-Cyclodextrin Complexes

Panoraia I Siafaka; Neslihan Üstündağ Okur; Mariza Mone; Spyridoula Giannakopoulou; Sevda Er; Eleni Pavlidou; Evangelos Karavas; Dimitrios N Bikiaris

doi:10.3390/ijms17030282

Two Different Approaches for Oral Administration of Voriconazole Loaded Formulations: Electrospun Fibers versus β-Cyclodextrin Complexes

Int J Mol Sci. 2016 Feb 25;17(3):282. doi: 10.3390/ijms17030282.

Authors

Panoraia I Siafaka¹, Neslihan Üstündağ Okur², Mariza Mone³, Spyridoula Giannakopoulou⁴, Sevda Er⁵, Eleni Pavlidou⁶, Evangelos Karavas⁷, Dimitrios N Bikiaris⁸

Affiliations

¹ Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54 124 Thessaloniki, Greece. siafpan@gmail.com.
² School of Pharmacy, Department of Pharmaceutical Technology, Istanbul Medipol University, Beykoz, 34810 Istanbul, Turkey. nustundag@medipol.edu.tr.
³ Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54 124 Thessaloniki, Greece. mariza_mone@hotmail.com.
⁴ Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54 124 Thessaloniki, Greece. spiretta@hotmail.com.
⁵ School of Pharmacy, Department of Microbiology, Istanbul Medipol University, Beykoz, 34810 Istanbul, Turkey. ser@medipol.edu.tr.
⁶ Department of Physics, Aristotle University of Thessaloniki, 54 124 Thessaloniki, Greece. etpavlid@auth.gr.
⁷ Pharmathen S.A, Dervenakion Str. 6, 153 51 Attiki, Greece. ekaravas@pharmathen.gr.
⁸ Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54 124 Thessaloniki, Greece. dbic@chem.auth.gr.

Abstract

In this work, a comparison between two different preparation methods for the improvement of dissolution rate of an antifungal agent is presented. Poly(ε-caprolactone) (PCL) electrospun fibers and β-cyclodextrin (β-CD) complexes, which were produced via an electrospinning process and an inclusion complexation method, respectively, were addressed for the treatment of fungal infections. Voriconazole (VRCZ) drug was selected as a model drug. PCL nanofibers were characterized on the basis of morphology while phase solubility studies for β-CDs complexes were performed. Various concentrations (5, 10, 15 and 20 wt %) of VRCZ were loaded to PCL fibers and β-CD inclusions to study the in vitro release profile as well as in vitro antifungal activity. The results clearly indicated that all formulations showed an improved VRCZ solubility and can inhibit fungi proliferation.

Keywords: PCL; antifungal; fibers; inclusion complexation; voriconazole drug.

MeSH terms

Administration, Oral
Antifungal Agents / administration & dosage*
Antifungal Agents / pharmacology
Candida / drug effects
Drug Carriers / chemistry*
Drug Liberation
Nanofibers / chemistry*
Polyesters / chemistry
Voriconazole / administration & dosage*
Voriconazole / pharmacology
beta-Cyclodextrins / chemistry*

Substances

Antifungal Agents
Drug Carriers
Polyesters
beta-Cyclodextrins
polycaprolactone
Voriconazole