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Page 1
Peptide-based covalent inhibitors of MALT1 paracaspase.
Hatcher JM, Du G, Fontán L, Us I, Qiao Q, Chennamadhavuni S, Shao J, Wu H, Melnick A, Gray NS, Scott DA. Hatcher JM, et al. Among authors: chennamadhavuni s. Bioorg Med Chem Lett. 2019 Jun 1;29(11):1336-1339. doi: 10.1016/j.bmcl.2019.03.046. Epub 2019 Mar 29. Bioorg Med Chem Lett. 2019. PMID: 30954428
How proteins bind macrocycles.
Villar EA, Beglov D, Chennamadhavuni S, Porco JA Jr, Kozakov D, Vajda S, Whitty A. Villar EA, et al. Among authors: chennamadhavuni s. Nat Chem Biol. 2014 Sep;10(9):723-31. doi: 10.1038/nchembio.1584. Epub 2014 Jul 20. Nat Chem Biol. 2014. PMID: 25038790 Free PMC article.
Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1.
Trilles R, Beglov D, Chen Q, He H, Wireman R, Reed A, Chennamadhavuni S, Panek JS, Brown LE, Vajda S, Porco JA Jr, Kelley MR, Georgiadis MM. Trilles R, et al. Among authors: chennamadhavuni s. J Med Chem. 2019 Feb 28;62(4):1971-1988. doi: 10.1021/acs.jmedchem.8b01529. Epub 2019 Feb 6. J Med Chem. 2019. PMID: 30653918 Free PMC article.
Brønsted acid-catalyzed imine amidation.
Rowland GB, Zhang H, Rowland EB, Chennamadhavuni S, Wang Y, Antilla JC. Rowland GB, et al. Among authors: chennamadhavuni s. J Am Chem Soc. 2005 Nov 16;127(45):15696-7. doi: 10.1021/ja0533085. J Am Chem Soc. 2005. PMID: 16277499
Inhibition of breast cancer metastasis to the lungs with UBS109.
Shoji M, Qian WP, Nagaraju GP, Brat DJ, Pessolano D, Luzietti R, Chennamadhavuni S, Yamaguchi M, Yang L, Liotta DC. Shoji M, et al. Among authors: chennamadhavuni s. Oncotarget. 2018 Nov 16;9(90):36102-36109. doi: 10.18632/oncotarget.26302. eCollection 2018 Nov 16. Oncotarget. 2018. PMID: 30546830 Free PMC article.
Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth.
Fontán L, Qiao Q, Hatcher JM, Casalena G, Us I, Teater M, Durant M, Du G, Xia M, Bilchuk N, Chennamadhavuni S, Palladino G, Inghirami G, Philippar U, Wu H, Scott DA, Gray NS, Melnick A. Fontán L, et al. Among authors: chennamadhavuni s. J Clin Invest. 2018 Oct 1;128(10):4397-4412. doi: 10.1172/JCI99436. Epub 2018 Jul 19. J Clin Invest. 2018. PMID: 30024860 Free PMC article.