Synthesis of benzoxazinone derivatives: a new route to 2 (N phthaloylmethyl)-4H-3,1-benzoxazin-4-one

Mehdi Shariat; Sohrab Abdollahi

doi:10.3390/90800705

Synthesis of benzoxazinone derivatives: a new route to 2 (N phthaloylmethyl)-4H-3,1-benzoxazin-4-one

Molecules. 2004 Jul 31;9(8):705-12. doi: 10.3390/90800705.

Authors

Mehdi Shariat¹, Sohrab Abdollahi

Affiliation

¹ Department of Chemistry, Payamnoor University of Golpayegan, Golpayegan, Iran.

Abstract

A new method has been designed to prepare the known benzoxazinone derivative 2-(N-phthaloylmethyl)-4H-3,1-benzoxazin-4-one (4). The acyl chloride derivative N-phthaloylglycine reacts with anthranilic acid in chloroform, in the presence of triethylamine, to give an intermediate that is then reacted with cyanuric chloride, used as a cyclization agent, to produce the benzoxazinone derivative.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzoxazines / chemical synthesis*
Benzoxazines / chemistry

Substances

2-(N phthaloylmethyl)-4H-3,1-benzoxazin-4-one
Benzoxazines