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Showing results for sirna fang
Search for Siran Fang instead (3 results)
Lipid nanoparticles produce chimeric antigen receptor T cells with interleukin-6 knockdown in vivo.
Zhou JE, Sun L, Jia Y, Wang Z, Luo T, Tan J, Fang X, Zhu H, Wang J, Yu L, Yan Z. Zhou JE, et al. J Control Release. 2022 Oct;350:298-307. doi: 10.1016/j.jconrel.2022.08.033. Epub 2022 Aug 25. J Control Release. 2022. PMID: 36002054
In this study, we constructed a lipid nanoparticle system modified by CD3 antibody on the surface, loading with the plasmid containing the combination gene of interleukin 6 short hairpin RNA (IL-6 shRNA) and CD19-CAR (AntiCD3-LNP/CAR19 + shIL6). The system targeted T cells …
In this study, we constructed a lipid nanoparticle system modified by CD3 antibody on the surface, loading with the plasmid containing the c …
Targeted gene silencing in vivo by platelet membrane-coated metal-organic framework nanoparticles.
Zhuang J, Gong H, Zhou J, Zhang Q, Gao W, Fang RH, Zhang L. Zhuang J, et al. Sci Adv. 2020 Mar 27;6(13):eaaz6108. doi: 10.1126/sciadv.aaz6108. eCollection 2020 Mar. Sci Adv. 2020. PMID: 32258408 Free PMC article.
Small interfering RNA (siRNA) is a powerful tool for gene silencing that has been used for a wide range of biomedical applications, but there are many challenges facing its therapeutic use in vivo. ...Overall, the biomimetic nanodelivery system present …
Small interfering RNA (siRNA) is a powerful tool for gene silencing that has been used for a wide range of biome …
Nano-scale delivery systems for siRNA delivery in cancer therapy: New era of gene therapy empowered by nanotechnology.
Ebrahimi N, Manavi MS, Nazari A, Momayezi A, Faghihkhorasani F, Rasool Riyadh Abdulwahid AH, Rezaei-Tazangi F, Kavei M, Rezaei R, Mobarak H, Aref AR, Fang W. Ebrahimi N, et al. Environ Res. 2023 Dec 15;239(Pt 2):117263. doi: 10.1016/j.envres.2023.117263. Epub 2023 Oct 4. Environ Res. 2023. PMID: 37797672 Free article. Review.
However, difficulties such poor cellular uptake, off-target effects, and susceptibility to destruction by serum nucleases in the bloodstream restrict the therapeutic potential of siRNAs. Since some years ago, siRNA-based therapies have been in the process of being t …
However, difficulties such poor cellular uptake, off-target effects, and susceptibility to destruction by serum nucleases in the bloodstream …
TMEM232 promotes the inflammatory response in atopic dermatitis via the nuclear factor-κB and signal transducer and activator of transcription 3 signalling pathways.
Han J, Cai X, Qin S, Zhang Z, Wu Y, Shi Y, Deng T, Chen B, Liu L, Qian H, Fang W, Xiao F. Han J, et al. Br J Dermatol. 2023 Jul 17;189(2):195-209. doi: 10.1093/bjd/ljad078. Br J Dermatol. 2023. PMID: 36928730
The role of TMEM232 in AD was analysed in HaCaT cells and Tmem232 knockout (Tmem232-/-) mice. Tmem232-specific small interfering RNA (siRNA) was used to evaluate its therapeutic potential in the AD mouse model. ...In vitro and in vivo experiments furth …
The role of TMEM232 in AD was analysed in HaCaT cells and Tmem232 knockout (Tmem232-/-) mice. Tmem232-specific small interfering …
AF9 sustains glycolysis in colorectal cancer via H3K9ac-mediated PCK2 and FBP1 transcription.
He X, Zhong X, Fang Y, Hu Z, Chen Z, Wang Y, Huang H, Zhao S, Li D, Wei P. He X, et al. Clin Transl Med. 2023 Aug;13(8):e1352. doi: 10.1002/ctm2.1352. Clin Transl Med. 2023. PMID: 37565737 Free PMC article.
METHODS: To investigate the function of AF9 in CRC, we utilised small interfering RNAs (siRNAs) to knock down the expression of 591 ERFs. ...Additionally, an Azoxymethane-Dextran Sodium Sulfate (AOM/DSS) induced CRC AF9(IEC-/-) mouse model was employed to con …
METHODS: To investigate the function of AF9 in CRC, we utilised small interfering RNAs (siRNAs) to knock down the expre …
siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference.
Fang Z, Zhao Z, Eapen V, Clarke RA. Fang Z, et al. Genes (Basel). 2021 Aug 23;12(8):1290. doi: 10.3390/genes12081290. Genes (Basel). 2021. PMID: 34440463 Free PMC article.
Exogenous siRNAs can target mRNAs within the cytosol as well as nascent RNA transcripts within the nucleus, thus complicating siRNA targeting specificity. ...These findings have implications for the design and application of RNA and DNA targeting techn …
Exogenous siRNAs can target mRNAs within the cytosol as well as nascent RNA transcripts within the nucleus, thus complicating …
Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma.
Hu L, Zhang Y, Guo L, Zhong H, Xie L, Zhou J, Liao C, Yao H, Fang J, Liu H, Zhang C, Zhang H, Zhu X, Luo M, von Kriegsheim A, Li B, Luo W, Zhang X, Chen X, Mendell JT, Xu L, Kapur P, Baldwin AS, Brugarolas J, Zhang Q. Hu L, et al. Mol Cell. 2024 Feb 15;84(4):776-790.e5. doi: 10.1016/j.molcel.2023.12.010. Epub 2024 Jan 10. Mol Cell. 2024. PMID: 38211588
One approach to overcome this challenge would be to identify an upstream TBK1 regulator that could be targeted therapeutically in cancer specifically. In this study, we perform a kinome-wide small interfering RNA (siRNA) screen and identify doublecorti …
One approach to overcome this challenge would be to identify an upstream TBK1 regulator that could be targeted therapeutically in cancer spe …
Photoacoustic image-guided biomimetic nanoparticles targeting rheumatoid arthritis.
Chen J, Zeng S, Xue Q, Hong Y, Liu L, Song L, Fang C, Zhang H, Wang B, Sedgwick AC, Zhang P, Sessler JL, Liu C, Chen J. Chen J, et al. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2213373119. doi: 10.1073/pnas.2213373119. Epub 2022 Oct 18. Proc Natl Acad Sci U S A. 2022. PMID: 36256822 Free PMC article.
Targeting strategies that integrate effective RAM regulation with imaging-based monitoring could lead to improvements in the diagnosis and treatment of RA. Here, we report the combined use of small interfering RNAs (siRNAs(T/I)) and Prussian blue nanoparticle …
Targeting strategies that integrate effective RAM regulation with imaging-based monitoring could lead to improvements in the diagnosis and t …
Nanoparticle-mediated systemic delivery of siRNA for treatment of cancers and viral infections.
Draz MS, Fang BA, Zhang P, Hu Z, Gu S, Weng KC, Gray JW, Chen FF. Draz MS, et al. Theranostics. 2014 Jun 11;4(9):872-92. doi: 10.7150/thno.9404. eCollection 2014. Theranostics. 2014. PMID: 25057313 Free PMC article. Review.
RNA interference (RNAi) is an endogenous post-transcriptional gene regulatory mechanism, where non-coding, double-stranded RNA molecules interfere with the expression of certain genes in order to silence it. Since its discovery, this phenomenon has evolved as powerf …
RNA interference (RNAi) is an endogenous post-transcriptional gene regulatory mechanism, where non-coding, double-stranded RNA …
Noninvasive approach for enhancing small interfering RNA delivery percutaneously.
Aljuffali IA, Lin YK, Fang JY. Aljuffali IA, et al. Expert Opin Drug Deliv. 2016;13(2):265-80. doi: 10.1517/17425247.2016.1121988. Epub 2015 Dec 7. Expert Opin Drug Deliv. 2016. PMID: 26592090 Review.
INTRODUCTION: Topically applied small interfering RNA (siRNA) can be an effective treatment for skin disorders. Using noninvasive strategies can be a safe and effective siRNA-permeation-enhancement approach for facilitating skin delivery. ...
INTRODUCTION: Topically applied small interfering RNA (siRNA) can be an effective treatment for skin disorders. …
1,987 results