Mild photothermal therapy assist in promoting bone repair: Related mechanism and materials

Zehao Yu; Hao Wang; Boda Ying; Xiaohan Mei; Dapeng Zeng; Shibo Liu; Wenrui Qu; Xiangjun Pan; Si Pu; Ruiyan Li; Yanguo Qin

doi:10.1016/j.mtbio.2023.100834

Mild photothermal therapy assist in promoting bone repair: Related mechanism and materials

Mater Today Bio. 2023 Oct 20:23:100834. doi: 10.1016/j.mtbio.2023.100834. eCollection 2023 Dec.

Authors

Zehao Yu^{1

2}, Hao Wang^{1

2}, Boda Ying^{1

2}, Xiaohan Mei³, Dapeng Zeng^{1

2}, Shibo Liu^{1

2}, Wenrui Qu^{1

2}, Xiangjun Pan^{1

2}, Si Pu^{1

2}, Ruiyan Li^{1

2}, Yanguo Qin^{1

2}

Affiliations

¹ Department of Joint Surgery of Orthopaedic Center, The Second Hospital of Jilin University, Changchun, 130041, People's Republic of China.
² Jilin Provincial Key Laboratory of Orhtopeadics, Changchun, Jilin 130041 People's Republic of China.
³ National & Local Joint Engineering Laboratory for Synthesis Technology of High-Performance Polymer, College of Chemistry, Jilin University, Changchun, 130012, People's Republic of China.

Abstract

Achieving precision treatment in bone tissue engineering (BTE) remains a challenge. Photothermal therapy (PTT), as a form of precision therapy, has been extensively investigated for its safety and efficacy. It has demonstrated significant potential in the treatment of orthopedic diseases such as bone tumors, postoperative infections and osteoarthritis. However, the high temperatures associated with PTT can lead to certain limitations and drawbacks. In recent years, researchers have explored the use of biomaterials for mild photothermal therapy (MPT), which offers a promising approach for addressing these limitations. This review provides a comprehensive overview of the mechanisms underlying MPT and presents a compilation of photothermal agents and their utilization strategies for bone tissue repair. Additionally, the paper discusses the future prospects of MPT-assisted bone tissue regeneration, aiming to provide insights and recommendations for optimizing material design in this field.

Keywords: Bone repair; Materials design; Mild temperature; Photothermal therapy.

Publication types

Review