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Intestinal commensal microbiota and cytokines regulate Fut2+ Paneth cells for gut defense.
Kamioka M, Goto Y, Nakamura K, Yokoi Y, Sugimoto R, Ohira S, Kurashima Y, Umemoto S, Sato S, Kunisawa J, Takahashi Y, Domino SE, Renauld JC, Nakae S, Iwakura Y, Ernst PB, Ayabe T, Kiyono H. Kamioka M, et al. Among authors: ohira s. Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):e2115230119. doi: 10.1073/pnas.2115230119. Proc Natl Acad Sci U S A. 2022. PMID: 35027453 Free PMC article.
Decreased Paneth cell α-defensins promote fibrosis in a choline-deficient L-amino acid-defined high-fat diet-induced mouse model of nonalcoholic steatohepatitis via disrupting intestinal microbiota.
Nakamura S, Nakamura K, Yokoi Y, Shimizu Y, Ohira S, Hagiwara M, Song Z, Gan L, Aizawa T, Hashimoto D, Teshima T, Ouellette AJ, Ayabe T. Nakamura S, et al. Among authors: ohira s. Sci Rep. 2023 Mar 9;13(1):3953. doi: 10.1038/s41598-023-30997-y. Sci Rep. 2023. PMID: 36894646 Free PMC article.