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2003 5
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Page 1
Showing results for shrna feng
Search for Shuna Feng instead (1 results)
siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice.
Tao W, Yurdagul A Jr, Kong N, Li W, Wang X, Doran AC, Feng C, Wang J, Islam MA, Farokhzad OC, Tabas I, Shi J. Tao W, et al. Sci Transl Med. 2020 Jul 22;12(553):eaay1063. doi: 10.1126/scitranslmed.aay1063. Sci Transl Med. 2020. PMID: 32718990 Free PMC article.
Atherosclerotic lesional macrophages express molecules that promote plaque progression, but lack of mechanisms to therapeutically target these molecules represents a major gap in translational cardiovascular research. Here, we tested the efficacy of a small interfering
Atherosclerotic lesional macrophages express molecules that promote plaque progression, but lack of mechanisms to therapeutically target the …
Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines.
Zhang Y, Kong Y, Ma Y, Ni S, Wikerholmen T, Xi K, Zhao F, Zhao Z, Wang J, Huang B, Chen A, Yao Z, Han M, Feng Z, Hu Y, Thorsen F, Wang J, Li X. Zhang Y, et al. Oncogene. 2021 Feb;40(8):1425-1439. doi: 10.1038/s41388-020-01622-3. Epub 2021 Jan 8. Oncogene. 2021. PMID: 33420375 Free PMC article.
SiRNA knockdown of COPZ1 suppressed proliferation of U87MG, U251 and P3#GBM in vitro. Stable expression of a COPZ1 shRNA construct in U87MG inhibited tumor growth in vivo by ~60% relative to controls at day 21 after implantation (P < 0.001). ...
SiRNA knockdown of COPZ1 suppressed proliferation of U87MG, U251 and P3#GBM in vitro. Stable expression of a COPZ1 shRNA construct in …
Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening.
McDonald ER 3rd, de Weck A, Schlabach MR, Billy E, Mavrakis KJ, Hoffman GR, Belur D, Castelletti D, Frias E, Gampa K, Golji J, Kao I, Li L, Megel P, Perkins TA, Ramadan N, Ruddy DA, Silver SJ, Sovath S, Stump M, Weber O, Widmer R, Yu J, Yu K, Yue Y, Abramowski D, Ackley E, Barrett R, Berger J, Bernard JL, Billig R, Brachmann SM, Buxton F, Caothien R, Caushi JX, Chung FS, Cortés-Cros M, deBeaumont RS, Delaunay C, Desplat A, Duong W, Dwoske DA, Eldridge RS, Farsidjani A, Feng F, Feng J, Flemming D, Forrester W, Galli GG, Gao Z, Gauter F, Gibaja V, Haas K, Hattenberger M, Hood T, Hurov KE, Jagani Z, Jenal M, Johnson JA, Jones MD, Kapoor A, Korn J, Liu J, Liu Q, Liu S, Liu Y, Loo AT, Macchi KJ, Martin T, McAllister G, Meyer A, Mollé S, Pagliarini RA, Phadke T, Repko B, Schouwey T, Shanahan F, Shen Q, Stamm C, Stephan C, Stucke VM, Tiedt R, Varadarajan M, Venkatesan K, Vitari AC, Wallroth M, Weiler J, Zhang J, Mickanin C, Myer VE, Porter JA, Lai A, Bitter H, Lees E, Keen N, Kauffmann A, Stegmeier F, Hofmann F, Schmelzle T, Sellers WR. McDonald ER 3rd, et al. Cell. 2017 Jul 27;170(3):577-592.e10. doi: 10.1016/j.cell.2017.07.005. Cell. 2017. PMID: 28753431 Free article.
To identify vulnerabilities relevant to specific cancer subtypes, we conducted a large-scale RNAi screen in which viability effects of mRNA knockdown were assessed for 7,837 genes using an average of 20 shRNAs per gene in 398 cancer cell lines. We describe findings of this …
To identify vulnerabilities relevant to specific cancer subtypes, we conducted a large-scale RNAi screen in which viability effects of mRNA …
siRNA-based nanomedicine.
Zhao J, Mi Y, Feng SS. Zhao J, et al. Nanomedicine (Lond). 2013 Jun;8(6):859-62. doi: 10.2217/nnm.13.73. Nanomedicine (Lond). 2013. PMID: 23730692 Free article. No abstract available.
Gαi1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis.
Li Y, Chai JL, Shi X, Feng Y, Li JJ, Zhou LN, Cao C, Li KR. Li Y, et al. Theranostics. 2023 Apr 17;13(7):2319-2336. doi: 10.7150/thno.80749. eCollection 2023. Theranostics. 2023. PMID: 37153740 Free PMC article.
Netrin-1-induced human umbilical vein endothelial cell (HUVEC) proliferation, migration and tube formation were inhibited by Galphai1/3 short hairpin RNA (shRNA), but were potentiated by ectopic Galphai1/3 overexpression. In vivo, intravitreous injection of Netrin-1 …
Netrin-1-induced human umbilical vein endothelial cell (HUVEC) proliferation, migration and tube formation were inhibited by Galphai1/3 shor …
Noncoding RNAs and pancreatic cancer.
Peng JF, Zhuang YY, Huang FT, Zhang SN. Peng JF, et al. World J Gastroenterol. 2016 Jan 14;22(2):801-14. doi: 10.3748/wjg.v22.i2.801. World J Gastroenterol. 2016. PMID: 26811626 Free PMC article. Review.
Noncoding RNAs (ncRNAs) represent a class of RNA molecules that typically do not code for proteins. Emerging data suggest that ncRNAs play an important role in several physiological and pathological conditions such as cancer. The best-characterized ncRNAs are the microRNAs …
Noncoding RNAs (ncRNAs) represent a class of RNA molecules that typically do not code for proteins. Emerging data suggest that ncRNAs …
The OsSGS3-tasiRNA-OsARF3 module orchestrates abiotic-biotic stress response trade-off in rice.
Gu X, Si F, Feng Z, Li S, Liang D, Yang P, Yang C, Yan B, Tang J, Yang Y, Li T, Li L, Zhou J, Li J, Feng L, Liu JY, Yang Y, Deng Y, Wu XN, Zhao Z, Wan J, Cao X, Song X, He Z, Liu J. Gu X, et al. Nat Commun. 2023 Jul 24;14(1):4441. doi: 10.1038/s41467-023-40176-2. Nat Commun. 2023. PMID: 37488129 Free PMC article.
OsSGS3a interacts with its homolog OsSGS3b and modulates the biogenesis of trans-acting small interfering RNA (tasiRNA) targeting AUXIN RESPONSE FACTORS (ARFs). ...
OsSGS3a interacts with its homolog OsSGS3b and modulates the biogenesis of trans-acting small interfering RNA (tasiRNA) …
ILGBMSH: an interpretable classification model for the shRNA target prediction with ensemble learning algorithm.
Zhao C, Xu N, Tan J, Cheng Q, Xie W, Xu J, Wei Z, Ye J, Yu L, Feng W. Zhao C, et al. Brief Bioinform. 2022 Nov 19;23(6):bbac429. doi: 10.1093/bib/bbac429. Brief Bioinform. 2022. PMID: 36184189
Short hairpin RNA (shRNA)-mediated gene silencing is an important technology to achieve RNA interference, in which the design of potent and reliable shRNA molecules plays a crucial role. ...Rather than utilizing only the shRNA sequence feature, …
Short hairpin RNA (shRNA)-mediated gene silencing is an important technology to achieve RNA interference, in which the …
Silencing circSERPINE2 restrains mesenchymal stem cell senescence via the YBX3/PCNA/p21 axis.
Chen F, Wang S, Zeng C, Tang S, Gu H, Wang Z, Li J, Feng P, Zhang Y, Wang P, Wu Y, Shen H. Chen F, et al. Cell Mol Life Sci. 2023 Oct 13;80(11):325. doi: 10.1007/s00018-023-04975-6. Cell Mol Life Sci. 2023. PMID: 37831180 Free PMC article.
CircSERPINE2 small interfering RNA delayed MSC senescence and rejuvenated MSCs, while circSERPINE2 overexpression had the opposite effect. RNA pulldown followed by mass spectrometry revealed an interaction between circSERPINE2 and YBX3. ...
CircSERPINE2 small interfering RNA delayed MSC senescence and rejuvenated MSCs, while circSERPINE2 overexpression had t …
1,864 results