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Molecular mechanism of cell cycle blockage of hepatoma SK-Hep-1 cells by Epimedin C through suppression of mitogen-activated protein kinase activation and increased expression of CDK inhibitors p21(Cip1) and p27(Kip1).
Liu TZ, Chen CY, Yiin SJ, Chen CH, Cheng JT, Shih MK, Wang YS, Chern CL. Liu TZ, et al. Among authors: yiin sj. Food Chem Toxicol. 2006 Feb;44(2):227-35. doi: 10.1016/j.fct.2005.07.003. Epub 2005 Aug 19. Food Chem Toxicol. 2006. PMID: 16112786
Isoobtusilactone A-induced apoptosis in human hepatoma Hep G2 cells is mediated via increased NADPH oxidase-derived reactive oxygen species (ROS) production and the mitochondria-associated apoptotic mechanisms.
Chen CY, Liu TZ, Chen CH, Wu CC, Cheng JT, Yiin SJ, Shih MK, Wu MJ, Chern CL. Chen CY, et al. Among authors: yiin sj. Food Chem Toxicol. 2007 Jul;45(7):1268-76. doi: 10.1016/j.fct.2007.01.008. Epub 2007 Jan 20. Food Chem Toxicol. 2007. PMID: 17321026
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