New Cytotoxic Terpenoids from Soft Corals Nephthea chabroli and Paralemnalia thyrsoides

Yu-Sheng Lee; Tsai-Hui Duh; Shu-Sheng Siao; Rey-Chang Chang; Shang-Kwei Wang; Chang-Yih Duh

doi:10.3390/md15120392

New Cytotoxic Terpenoids from Soft Corals Nephthea chabroli and Paralemnalia thyrsoides

Mar Drugs. 2017 Dec 19;15(12):392. doi: 10.3390/md15120392.

Authors

Yu-Sheng Lee¹, Tsai-Hui Duh², Shu-Sheng Siao³, Rey-Chang Chang⁴, Shang-Kwei Wang⁵, Chang-Yih Duh⁶

Affiliations

¹ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. m995020028@student.nsysu.edu.tw.
² Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan. tshudu@kmu.edu.tw.
³ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. m035020008@student.nsysu.edu.tw.
⁴ Department of Marine Biotechnology, National Kaohsiung Marine University, Kaohsiung 811, Taiwan. rcchang@mail.nkmu.edu.tw.
⁵ Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan. skwang@cc.kmu.edu.tw.
⁶ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. yihduh@mail.nsysu.edu.tw.

Abstract

A novel cytotoxic diterpenoid, chabrolin A (1) (possessing an unprecedented terpenoid skeleton), as well as three new cytotoxic sesquiterpenoids, parathyrsoidins E-G (2-4), were isolated by cytotoxicity-guided fractionation from soft corals Nephtheachabroli and Paralemnalia thyrsoides. The structures of the new compounds were determined by extensive analysis of spectroscopic data.

Keywords: Nephthea chabroli; Paralemnalia thyrsoides; cytotoxicity.

MeSH terms

Animals
Anthozoa / chemistry*
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Antiviral Agents / isolation & purification
Antiviral Agents / pharmacology
Cell Line, Tumor
Cells, Cultured
Chemical Fractionation / methods
Cytomegalovirus / drug effects
Humans
Mice
Molecular Structure
Spectrum Analysis / methods
Terpenes / chemistry
Terpenes / isolation & purification
Terpenes / pharmacology*

Substances

Antineoplastic Agents
Antiviral Agents
Terpenes