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Page 1
Babesia duncani multi-omics identifies virulence factors and drug targets.
Singh P, Lonardi S, Liang Q, Vydyam P, Khabirova E, Fang T, Gihaz S, Thekkiniath J, Munshi M, Abel S, Ciampossin L, Batugedara G, Gupta M, Lu XM, Lenz T, Chakravarty S, Cornillot E, Hu Y, Ma W, Gonzalez LM, Sánchez S, Estrada K, Sánchez-Flores A, Montero E, Harb OS, Le Roch KG, Mamoun CB. Singh P, et al. Among authors: gihaz s. Nat Microbiol. 2023 May;8(5):845-859. doi: 10.1038/s41564-023-01360-8. Epub 2023 Apr 13. Nat Microbiol. 2023. PMID: 37055610 Free PMC article.
High-resolution crystal structure and chemical screening reveal pantothenate kinase as a new target for antifungal development.
Gihaz S, Gareiss P, Choi JY, Renard I, Pal AC, Surovsteva Y, Chiu JE, Thekkiniath J, Plummer M, Hungerford W, Montgomery ML, Hosford A, Adams EM, Lightfoot JD, Fox D 3rd, Ojo KK, Staker BL, Fuller K, Ben Mamoun C. Gihaz S, et al. Structure. 2022 Nov 3;30(11):1494-1507.e6. doi: 10.1016/j.str.2022.09.001. Epub 2022 Sep 26. Structure. 2022. PMID: 36167065 Free PMC article.
Effective Therapy Targeting Cytochrome bc1 Prevents Babesia Erythrocytic Development and Protects from Lethal Infection.
Chiu JE, Renard I, Pal AC, Singh P, Vydyam P, Thekkiniath J, Kumar M, Gihaz S, Pou S, Winter RW, Dodean R, Frueh L, Nilsen AC, Riscoe MK, Doggett JS, Mamoun CB. Chiu JE, et al. Among authors: gihaz s. Antimicrob Agents Chemother. 2021 Aug 17;65(9):e0066221. doi: 10.1128/AAC.00662-21. Epub 2021 Aug 17. Antimicrob Agents Chemother. 2021. PMID: 34152821 Free PMC article.
12 results