Calculating degree based multiplicative topological indices of Hyaluronic Acid-Paclitaxel conjugates' molecular structure in cancer treatment

J Biomol Struct Dyn. 2021 Sep;39(14):5304-5313. doi: 10.1080/07391102.2020.1800512. Epub 2020 Jul 30.

Abstract

A large number of medical experiments have confirmed that the features of drugs have a close correlation with their molecular structure. Drug properties can be obtained by studying the molecular structure of corresponding drugs. The calculation of the topological index of a drug structure enables scientists to have a better understanding of the physical chemistry and biological characteristics of drugs. In this paper, we focus on Hyaluronic Acid-Paclitaxel conjugates which are widely used in the manufacture of anticancer drugs. Several multiplicative topological indices of this molecular structure are determined by using of the edge-partition method.Communicated by Ramaswamy H. Sarma.

Keywords: 05C50; Multiplicative sum connectivity index; cancer treatment; multiplicative randić index.

MeSH terms

  • Antineoplastic Agents*
  • Humans
  • Hyaluronic Acid
  • Molecular Structure
  • Neoplasms* / drug therapy
  • Paclitaxel

Substances

  • Antineoplastic Agents
  • Hyaluronic Acid
  • Paclitaxel