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2019 1
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Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer's disease.
Iyaswamy A, Thakur A, Guan XJ, Krishnamoorthi S, Fung TY, Lu K, Gaurav I, Yang Z, Su CF, Lau KF, Zhang K, Ng RC, Lian Q, Cheung KH, Ye K, Chen HJ, Li M. Iyaswamy A, et al. Among authors: krishnamoorthi s. Signal Transduct Target Ther. 2023 Oct 23;8(1):404. doi: 10.1038/s41392-023-01657-4. Signal Transduct Target Ther. 2023. PMID: 37867176 Free PMC article.
Targeting Aggrephagy for the Treatment of Alzheimer's Disease.
Malampati S, Song JX, Chun-Kit Tong B, Nalluri A, Yang CB, Wang Z, Gopalkrishnashetty Sreenivasmurthy S, Zhu Z, Liu J, Su C, Krishnamoorthi S, Iyaswamy A, Cheung KH, Lu JH, Li AM. Malampati S, et al. Among authors: krishnamoorthi s. Cells. 2020 Jan 28;9(2):311. doi: 10.3390/cells9020311. Cells. 2020. PMID: 32012902 Free PMC article. Review.
Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease.
Tong BC, Wu AJ, Huang AS, Dong R, Malampati S, Iyaswamy A, Krishnamoorthi S, Sreenivasmurthy SG, Zhu Z, Su C, Liu J, Song J, Lu JH, Tan J, Pan W, Li M, Cheung KH. Tong BC, et al. Among authors: krishnamoorthi s. Autophagy. 2022 Mar;18(3):624-642. doi: 10.1080/15548627.2021.1945220. Epub 2021 Jul 27. Autophagy. 2022. PMID: 34313551 Free PMC article.
Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson's Disease.
Zhu Z, Yang C, Iyaswamy A, Krishnamoorthi S, Sreenivasmurthy SG, Liu J, Wang Z, Tong BC, Song J, Lu J, Cheung KH, Li M. Zhu Z, et al. Among authors: krishnamoorthi s. Int J Mol Sci. 2019 Feb 8;20(3):728. doi: 10.3390/ijms20030728. Int J Mol Sci. 2019. PMID: 30744070 Free PMC article. Review.
PPARɑ Ligand Caudatin Improves Cognitive Functions and Mitigates Alzheimer's Disease Defects By Inducing Autophagy in Mice Models.
Krishnamoorthi S, Iyaswamy A, Sreenivasmurthy SG, Thakur A, Vasudevan K, Kumar G, Guan XJ, Lu K, Gaurav I, Su CF, Zhu Z, Liu J, Kan Y, Jayaraman S, Deng Z, Chua KK, Cheung KH, Yang Z, Song JX, Li M. Krishnamoorthi S, et al. J Neuroimmune Pharmacol. 2023 Sep;18(3):509-528. doi: 10.1007/s11481-023-10083-w. Epub 2023 Sep 8. J Neuroimmune Pharmacol. 2023. PMID: 37682502
Real-Time Detection and Visualization of Amyloid-β Aggregates Induced by Hydrogen Peroxide in Cell and Mouse Models of Alzheimer's Disease.
Wang X, Iyaswamy A, Xu D, Krishnamoorthi S, Sreenivasmurthy SG, Yang Y, Li Y, Chen C, Li M, Li HW, Wong MS. Wang X, et al. Among authors: krishnamoorthi s. ACS Appl Mater Interfaces. 2023 Jan 11;15(1):39-47. doi: 10.1021/acsami.2c07859. Epub 2022 Jul 22. ACS Appl Mater Interfaces. 2023. PMID: 35866616 Free PMC article. Review.
Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy.
Zhu Z, Liu LF, Su CF, Liu J, Tong BC, Iyaswamy A, Krishnamoorthi S, Sreenivasmurthy SG, Guan XJ, Kan YX, Xie WJ, Zhao CL, Cheung KH, Lu JH, Tan JQ, Zhang HJ, Song JX, Li M. Zhu Z, et al. Among authors: krishnamoorthi s. Acta Pharmacol Sin. 2022 Oct;43(10):2511-2526. doi: 10.1038/s41401-022-00871-0. Epub 2022 Feb 25. Acta Pharmacol Sin. 2022. PMID: 35217810 Free PMC article.
Chronic oral administration of adipoRon reverses cognitive impairments and ameliorates neuropathology in an Alzheimer's disease mouse model.
Ng RC, Jian M, Ma OK, Bunting M, Kwan JS, Zhou GJ, Senthilkumar K, Iyaswamy A, Chan PK, Li M, Leung KM, Kumar Durairajan SS, Lam KS, Chu LW, Festenstein R, Chung SK, Chan KH. Ng RC, et al. Among authors: senthilkumar k. Mol Psychiatry. 2021 Oct;26(10):5669-5689. doi: 10.1038/s41380-020-0701-0. Epub 2020 Mar 4. Mol Psychiatry. 2021. PMID: 32132650
Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models.
Iyaswamy A, Wang X, Krishnamoorthi S, Kaliamoorthy V, Sreenivasmurthy SG, Kumar Durairajan SS, Song JX, Tong BC, Zhu Z, Su CF, Liu J, Cheung KH, Lu JH, Tan JQ, Li HW, Wong MS, Li M. Iyaswamy A, et al. Among authors: krishnamoorthi s. Redox Biol. 2022 May;51:102280. doi: 10.1016/j.redox.2022.102280. Epub 2022 Mar 8. Redox Biol. 2022. PMID: 35286997 Free PMC article.
15 results