Abstract
The purpose of this study is to describe the clinical case of a patient suffering from a gland carcinoma with bilateral inguinal and pelvic lymph node metastases in treatment with weekly administrations of Docetaxel. After two therapy cycles, the patient developed an atypical uremic hemolytic Syndrome (SEUa), treated with infusions of frozen fresh plasma, hemodialysis, and antibiotics. Because of a severe septic secondary complication on an extensive lymph node abscess, the administration of Eculizumab was not possible. The patient survived the mentioned Syndrome and is currently in periodic dialysis treatment.
Keywords:
Docetaxel; Eculizumab; aHUS.
Copyright by Società Italiana di Nefrologia SIN, Rome, Italy.
MeSH terms
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Anti-Bacterial Agents / therapeutic use
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Antibodies, Monoclonal, Humanized / therapeutic use
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Agents, Phytogenic / adverse effects*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Atypical Hemolytic Uremic Syndrome / chemically induced*
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Atypical Hemolytic Uremic Syndrome / therapy
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Carcinoma, Squamous Cell / drug therapy
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Carcinoma, Squamous Cell / surgery
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Cisplatin / administration & dosage
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Combined Modality Therapy
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Docetaxel
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Fluorouracil / administration & dosage
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Humans
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Lymph Node Excision
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Male
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Middle Aged
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Penile Neoplasms / drug therapy
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Penile Neoplasms / surgery
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Plasma
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Postoperative Complications / chemically induced
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Postoperative Complications / therapy
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Renal Dialysis
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Taxoids / administration & dosage
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Taxoids / adverse effects*
Substances
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Anti-Bacterial Agents
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Antibodies, Monoclonal, Humanized
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Antineoplastic Agents, Phytogenic
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Taxoids
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Docetaxel
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eculizumab
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Cisplatin
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Fluorouracil