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CRISPR/Cas9-Based Cellular Engineering for Targeted Gene Overexpression.
Osborn MJ, Lees CJ, McElroy AN, Merkel SC, Eide CR, Mathews W, Feser CJ, Tschann M, McElmury RT, Webber BR, Kim CJ, Blazar BR, Tolar J. Osborn MJ, et al. Among authors: merkel sc. Int J Mol Sci. 2018 Mar 22;19(4):946. doi: 10.3390/ijms19040946. Int J Mol Sci. 2018. PMID: 29565806 Free PMC article.
Multiply restimulated human thymic regulatory T cells express distinct signature regulatory T-cell transcription factors without evidence of exhaustion.
Hippen KL, Furlan SN, Roychoudhuri R, Wang E, Zhang Y, Osborn MJ, Merkel SC, Hani S, MacMillan ML, Cichocki F, Miller JS, Wagner JE, Restifo NP, Kean LS, Blazar BR. Hippen KL, et al. Among authors: merkel sc. Cytotherapy. 2021 Aug;23(8):704-714. doi: 10.1016/j.jcyt.2021.02.118. Epub 2021 Apr 20. Cytotherapy. 2021. PMID: 33893050 Free PMC article.
Optimization of cGMP purification and expansion of umbilical cord blood-derived T-regulatory cells in support of first-in-human clinical trials.
McKenna DH Jr, Sumstad D, Kadidlo DM, Batdorf B, Lord CJ, Merkel SC, Koellner CM, Curtsinger JM, June CH, Riley JL, Levine BL, Miller JS, Brunstein CG, Wagner JE, Blazar BR, Hippen KL. McKenna DH Jr, et al. Among authors: merkel sc. Cytotherapy. 2017 Feb;19(2):250-262. doi: 10.1016/j.jcyt.2016.10.011. Epub 2016 Nov 22. Cytotherapy. 2017. PMID: 27887864 Free PMC article.
Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells.
Hippen KL, Harker-Murray P, Porter SB, Merkel SC, Londer A, Taylor DK, Bina M, Panoskaltsis-Mortari A, Rubinstein P, Van Rooijen N, Golovina TN, Suhoski MM, Miller JS, Wagner JE, June CH, Riley JL, Blazar BR. Hippen KL, et al. Among authors: merkel sc. Blood. 2008 Oct 1;112(7):2847-57. doi: 10.1182/blood-2008-01-132951. Epub 2008 Jul 21. Blood. 2008. PMID: 18645038 Free PMC article.
Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity.
Hippen KL, Merkel SC, Schirm DK, Sieben CM, Sumstad D, Kadidlo DM, McKenna DH, Bromberg JS, Levine BL, Riley JL, June CH, Scheinberg P, Douek DC, Miller JS, Wagner JE, Blazar BR. Hippen KL, et al. Among authors: merkel sc. Sci Transl Med. 2011 May 18;3(83):83ra41. doi: 10.1126/scitranslmed.3001809. Sci Transl Med. 2011. PMID: 21593401 Free PMC article.