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Showing results for sandra coded
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Apoptotic cell death in disease-Current understanding of the NCCD 2023.
Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, Balachandran S, Bano D, Barlev NA, Bartek J, Bazan NG, Becker C, Bernassola F, Bertrand MJM, Bianchi ME, Blagosklonny MV, Blander JM, Blandino G, Blomgren K, Borner C, Bortner CD, Bove P, Boya P, Brenner C, Broz P, Brunner T, Damgaard RB, Calin GA, Campanella M, Candi E, Carbone M, Carmona-Gutierrez D, Cecconi F, Chan FK, Chen GQ, Chen Q, Chen YH, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Ciliberto G, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Daugaard M, Dawson TM, Dawson VL, De Maria R, De Strooper B, Debatin KM, Deberardinis RJ, Degterev A, Del Sal G, Deshmukh M, Di Virgilio F, Diederich M, Dixon SJ, Dynlacht BD, El-Deiry WS, Elrod JW, Engeland K, Fimia GM, Galassi C, Ganini C, Garcia-Saez AJ, Garg AD, Garrido C, Gavathiotis E, Gerlic M, Ghosh S, Green DR, Greene LA, Gronemeyer H, Häcker G, Hajnóczky G, Hardwick JM, Haupt Y, He S, Heery DM, Hengartner MO, Hetz C, Hildeman DA, Ichijo H, Inoue S, Jäättelä M, Janic A, Joseph B, Jost PJ, Kanneganti TD, Karin M, Kashkar H, Kaufmann T, Kelly … See abstract for full author list ➔ Vitale I, et al. Cell Death Differ. 2023 May;30(5):1097-1154. doi: 10.1038/s41418-023-01153-w. Epub 2023 Apr 26. Cell Death Differ. 2023. PMID: 37100955 Free article. Review.
Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease....
Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanisti …
The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities.
Nombela P, Miguel-López B, Blanco S. Nombela P, et al. Mol Cancer. 2021 Jan 18;20(1):18. doi: 10.1186/s12943-020-01263-w. Mol Cancer. 2021. PMID: 33461542 Free PMC article. Review.
Significant advances have been made in understanding the functional role of RNA modifications in regulating coding and non-coding RNA processing and function, which in turn thoroughly shape distinct gene expression programmes. ...In this Review, we focus on the occu …
Significant advances have been made in understanding the functional role of RNA modifications in regulating coding and non-coding
METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer.
García-Vílchez R, Añazco-Guenkova AM, Dietmann S, López J, Morón-Calvente V, D'Ambrosi S, Nombela P, Zamacola K, Mendizabal I, García-Longarte S, Zabala-Letona A, Astobiza I, Fernández S, Paniagua A, Miguel-López B, Marchand V, Alonso-López D, Merkel A, García-Tuñón I, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Azkargorta M, Elortza F, Bárcena L, Gonzalez-Lopez M, Aransay AM, Di Domenico T, Sánchez-Martín MA, De Las Rivas J, Guil S, Motorin Y, Helm M, Pandolfi PP, Carracedo A, Blanco S. García-Vílchez R, et al. Mol Cancer. 2023 Jul 29;22(1):119. doi: 10.1186/s12943-023-01809-8. Mol Cancer. 2023. PMID: 37516825 Free PMC article.
Mechanistically, we find that METTL1 depletion causes the loss of m(7)G tRNA methylation and promotes the biogenesis of a novel class of small non-coding RNAs derived from 5'tRNA fragments. 5'tRNA-derived small RNAs steer translation control to favour the synthesis of key …
Mechanistically, we find that METTL1 depletion causes the loss of m(7)G tRNA methylation and promotes the biogenesis of a novel class of sma …
Association of Progestogens and Venous Thromboembolism Among Women of Reproductive Age.
Cockrum RH, Soo J, Ham SA, Cohen KS, Snow SG. Cockrum RH, et al. Obstet Gynecol. 2022 Sep 1;140(3):477-487. doi: 10.1097/AOG.0000000000004896. Epub 2022 Aug 3. Obstet Gynecol. 2022. PMID: 35926206 Free PMC article.
After exclusions, 21,405 women with incident acute VTE (case group), identified by diagnosis codes, were matched 1:5 by year of birth and index date through risk set sampling to 107,025 women without prior VTE (control group). ...
After exclusions, 21,405 women with incident acute VTE (case group), identified by diagnosis codes, were matched 1:5 by year of birth …
Non-mutational neoantigens in disease.
Stern LJ, Clement C, Galluzzi L, Santambrogio L. Stern LJ, et al. Nat Immunol. 2024 Jan;25(1):29-40. doi: 10.1038/s41590-023-01664-1. Epub 2024 Jan 2. Nat Immunol. 2024. PMID: 38168954 Review.
Although it is widely believed that mature T cells are highly skewed towards the recognition of antigenic peptides originating from genetically diverse (for example, foreign or mutated) protein-coding regions, preclinical and clinical data rather demonstrate that no …
Although it is widely believed that mature T cells are highly skewed towards the recognition of antigenic peptides originating from genetica …
Using microRNA Networks to Understand Cancer.
Dragomir M, Mafra ACP, Dias SMG, Vasilescu C, Calin GA. Dragomir M, et al. Int J Mol Sci. 2018 Jun 26;19(7):1871. doi: 10.3390/ijms19071871. Int J Mol Sci. 2018. PMID: 29949872 Free PMC article. Review.
Additionally, many miRNAs regulate and are regulated by other species of non-coding RNAs, such as circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs). ...
Additionally, many miRNAs regulate and are regulated by other species of non-coding RNAs, such as circular RNAs (circRNAs) and long n …
Functional RNA during Zika virus infection.
Göertz GP, Abbo SR, Fros JJ, Pijlman GP. Göertz GP, et al. Virus Res. 2018 Aug 2;254:41-53. doi: 10.1016/j.virusres.2017.08.015. Epub 2017 Aug 31. Virus Res. 2018. PMID: 28864425 Free article. Review.
Furthermore, a number of host factors interact with the viral genome to modulate RNA replication. Importantly, the ZIKV genome produces non-coding subgenomic flavivirus RNA (sfRNA) due to stalling of host 5'- 3' ribonucleases on viral RNA structures in the 3' untranslated …
Furthermore, a number of host factors interact with the viral genome to modulate RNA replication. Importantly, the ZIKV genome produces non- …
Cellular RNA surveillance in health and disease.
Wolin SL, Maquat LE. Wolin SL, et al. Science. 2019 Nov 15;366(6467):822-827. doi: 10.1126/science.aax2957. Epub 2019 Nov 14. Science. 2019. PMID: 31727827 Free PMC article. Review.
These pathways monitor most steps in the biogenesis of both noncoding RNAs (ncRNAs) and protein-coding messenger RNAs (mRNAs), degrading ncRNAs that fail to form functional complexes with one or more proteins and eliminating mRNAs that encode abnormal, potentially toxic pr …
These pathways monitor most steps in the biogenesis of both noncoding RNAs (ncRNAs) and protein-coding messenger RNAs (mRNAs), degrad …
Cyclophilin polymorphism and virus infection.
von Hahn T, Ciesek S. von Hahn T, et al. Curr Opin Virol. 2015 Oct;14:47-9. doi: 10.1016/j.coviro.2015.07.012. Epub 2015 Aug 13. Curr Opin Virol. 2015. PMID: 26281011 Free PMC article. Review.
However, sequence variation also exists in host factors mostly in the form of single nucleotide polymorphisms (SNPs). Several coding and non-coding genetic variants in the PPIA gene encoding for CypA have been described, but there is only limited information about t …
However, sequence variation also exists in host factors mostly in the form of single nucleotide polymorphisms (SNPs). Several coding
Role of Polycomb in the control of transposable elements.
Déléris A, Berger F, Duharcourt S. Déléris A, et al. Trends Genet. 2021 Oct;37(10):882-889. doi: 10.1016/j.tig.2021.06.003. Epub 2021 Jun 28. Trends Genet. 2021. PMID: 34210514 Review.
It is generally considered that Polycomb Repressive Complex (PRC)2 deposits the histone mark H3K27me3 on silent protein-coding genes, while transposable elements are repressed by DNA and/or H3K9 methylation. ...
It is generally considered that Polycomb Repressive Complex (PRC)2 deposits the histone mark H3K27me3 on silent protein-coding genes, …
122 results