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Page 1
3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans.
Vermillion Maier ML, Siddens LK, Uesugi SL, Choi J, Leonard SW, Pennington JM, Tilton SC, Smith JN, Ho E, Chow HHS, Nguyen BD, Kolluri SK, Williams DE. Vermillion Maier ML, et al. Among authors: uesugi sl. Drug Metab Dispos. 2021 Aug;49(8):694-705. doi: 10.1124/dmd.120.000346. Epub 2021 May 25. Drug Metab Dispos. 2021. PMID: 34035125 Free PMC article.
Benzo[a]pyrene (BaP) metabolites predominant in human plasma following escalating oral micro-dosing with [14C]-BaP.
Vermillion Maier ML, Siddens LK, Pennington JM, Uesugi SL, Anderson KA, Tidwell LG, Tilton SC, Ognibene TJ, Turteltaub KW, Smith JN, Williams DE. Vermillion Maier ML, et al. Among authors: uesugi sl. Environ Int. 2022 Jan 15;159:107045. doi: 10.1016/j.envint.2021.107045. Epub 2021 Dec 15. Environ Int. 2022. PMID: 34920278 Free PMC article.
Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or Brussels sprouts.
Vermillion Maier ML, Siddens LK, Pennington JM, Uesugi SL, Tilton SC, Vertel EA, Anderson KA, Tidwell LG, Ognibene TJ, Turteltaub KW, Smith JN, Williams DE. Vermillion Maier ML, et al. Among authors: uesugi sl. Toxicol Appl Pharmacol. 2023 Feb 1;460:116377. doi: 10.1016/j.taap.2023.116377. Epub 2023 Jan 13. Toxicol Appl Pharmacol. 2023. PMID: 36642108 Free PMC article. Clinical Trial.
Impact of phenanthrene co-administration on the toxicokinetics of benzo[a]pyrene in humans. UPLC-accelerator mass spectrometry following oral microdosing.
Maier MLV, Siddens LK, Pennington JM, Uesugi SL, Labut EM, Vertel EA, Anderson KA, Tidwell LG, Tilton SC, Ognibene TJ, Turteltaub KW, Smith JN, Williams DE. Maier MLV, et al. Among authors: uesugi sl. Chem Biol Interact. 2023 Sep 1;382:110608. doi: 10.1016/j.cbi.2023.110608. Epub 2023 Jun 25. Chem Biol Interact. 2023. PMID: 37369263 Free PMC article.
Pharmacokinetics of [14C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction.
Hummel JM, Madeen EP, Siddens LK, Uesugi SL, McQuistan T, Anderson KA, Turteltaub KW, Ognibene TJ, Bench G, Krueger SK, Harris S, Smith J, Tilton SC, Baird WM, Williams DE. Hummel JM, et al. Among authors: uesugi sl. Food Chem Toxicol. 2018 May;115:136-147. doi: 10.1016/j.fct.2018.03.003. Epub 2018 Mar 5. Food Chem Toxicol. 2018. PMID: 29518434 Free PMC article.