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Year Number of Results
2008 1
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2013 2
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29 results

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Page 1
SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response.
Bland P, Saville H, Wai PT, Curnow L, Muirhead G, Nieminuszczy J, Ravindran N, John MB, Hedayat S, Barker HE, Wright J, Yu L, Mavrommati I, Read A, Peck B, Allen M, Gazinska P, Pemberton HN, Gulati A, Nash S, Noor F, Guppy N, Roxanis I, Pratt G, Oldreive C, Stankovic T, Barlow S, Kalirai H, Coupland SE, Broderick R, Alsafadi S, Houy A, Stern MH, Pettit S, Choudhary JS, Haider S, Niedzwiedz W, Lord CJ, Natrajan R. Bland P, et al. Among authors: alsafadi s. Nat Genet. 2023 Aug;55(8):1311-1323. doi: 10.1038/s41588-023-01460-5. Epub 2023 Jul 31. Nat Genet. 2023. PMID: 37524790 Free PMC article.
Patient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug target.
Groenewoud A, Yin J, Gelmi MC, Alsafadi S, Nemati F, Decaudin D, Roman-Roman S, Kalirai H, Coupland SE, Jochemsen AG, Jager MJ, Engel FB, Snaar-Jagalska BE. Groenewoud A, et al. Among authors: alsafadi s. Cell Death Discov. 2023 Jun 16;9(1):183. doi: 10.1038/s41420-023-01446-6. Cell Death Discov. 2023. PMID: 37321991 Free PMC article.
FAK Inhibitor-Based Combinations with MEK or PKC Inhibitors Trigger Synergistic Antitumor Effects in Uveal Melanoma.
Tarin M, Némati F, Decaudin D, Canbezdi C, Marande B, Silva L, Derrien H, Jochemsen AG, Gardrat S, Piperno-Neumann S, Rodrigues M, Mariani P, Cassoux N, Stern MH, Roman-Roman S, Alsafadi S. Tarin M, et al. Among authors: alsafadi s. Cancers (Basel). 2023 Apr 13;15(8):2280. doi: 10.3390/cancers15082280. Cancers (Basel). 2023. PMID: 37190207 Free PMC article.
Accelerated DNA replication fork speed due to loss of R-loops in myelodysplastic syndromes with SF3B1 mutation.
Rombaut D, Lefèvre C, Rached T, Bondu S, Letessier A, Mangione RM, Farhat B, Lesieur-Pasquier A, Castillo-Guzman D, Boussaid I, Friedrich C, Tourville A, De Carvalho M, Levavasseur F, Leduc M, Le Gall M, Battault S, Temple M, Houy A, Bouscary D, Willems L, Park S, Raynaud S, Cluzeau T, Clappier E, Fenaux P, Adès L, Margueron R, Wassef M, Alsafadi S, Chapuis N, Kosmider O, Solary E, Constantinou A, Stern MH, Droin N, Palancade B, Miotto B, Chédin F, Fontenay M. Rombaut D, et al. Among authors: alsafadi s. Nat Commun. 2024 Apr 8;15(1):3016. doi: 10.1038/s41467-024-46547-7. Nat Commun. 2024. PMID: 38589367 Free PMC article.
Glycolysis Dependency as a Hallmark of SF3B1-Mutated Cells.
Vivet-Noguer R, Tarin M, Canbezdi C, Dayot S, Silva L, Houy A, Martineau S, Mieulet V, Gentric G, Loew D, Lombard B, Nemati F, Richon S, Guyonnet L, Servois V, Vagner S, Stern MH, Roman-Roman S, Alsafadi S. Vivet-Noguer R, et al. Among authors: alsafadi s. Cancers (Basel). 2022 Apr 24;14(9):2113. doi: 10.3390/cancers14092113. Cancers (Basel). 2022. PMID: 35565242 Free PMC article.
P53 family: at the crossroads in cancer therapy.
Alsafadi S, Tourpin S, André F, Vassal G, Ahomadegbe JC. Alsafadi S, et al. Curr Med Chem. 2009;16(32):4328-44. doi: 10.2174/092986709789578196. Curr Med Chem. 2009. PMID: 19754415 Review.
Germline MBD4 Mutations and Predisposition to Uveal Melanoma.
Derrien AC, Rodrigues M, Eeckhoutte A, Dayot S, Houy A, Mobuchon L, Gardrat S, Lequin D, Ballet S, Pierron G, Alsafadi S, Mariani O, El-Marjou A, Matet A, Colas C, Cassoux N, Stern MH. Derrien AC, et al. Among authors: alsafadi s. J Natl Cancer Inst. 2021 Jan 4;113(1):80-87. doi: 10.1093/jnci/djaa047. J Natl Cancer Inst. 2021. PMID: 32239153 Free PMC article.
Cytidine analogs are synthetic lethal with base excision repair default due to MBD4 deficiency.
Chabot T, Nemati F, Herbette A, Demeyer A, Dayot S, Ganier O, Alsafadi S, Gardrat S, Mariani P, Luporsi M, Corbé M, Servois V, Cassoux N, Decaudin D, Roman SR, Del Nery E, Piperno-Neumann S, Stern MH, Rodrigues M. Chabot T, et al. Among authors: alsafadi s. NPJ Precis Oncol. 2022 Nov 2;6(1):81. doi: 10.1038/s41698-022-00326-z. NPJ Precis Oncol. 2022. PMID: 36323843 Free PMC article.
29 results