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Page 1
Showing results for sam create
Search for Sam Crease instead (1 results)
MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis.
Marjon K, Cameron MJ, Quang P, Clasquin MF, Mandley E, Kunii K, McVay M, Choe S, Kernytsky A, Gross S, Konteatis Z, Murtie J, Blake ML, Travins J, Dorsch M, Biller SA, Marks KM. Marjon K, et al. Cell Rep. 2016 Apr 19;15(3):574-587. doi: 10.1016/j.celrep.2016.03.043. Epub 2016 Apr 7. Cell Rep. 2016. PMID: 27068473 Free article.
MTAP-deleted cells have reduced PRMT5 methylation activity and increased sensitivity to PRMT5 depletion. MAT2A produces the PRMT5 substrate S-adenosylmethionine (SAM), and MAT2A depletion reduces growth and PRMT5 methylation activity selectively in MTAP-deleted cells. Furt …
MTAP-deleted cells have reduced PRMT5 methylation activity and increased sensitivity to PRMT5 depletion. MAT2A produces the PRMT5 substrate …
Mitigating Burnout.
Siegel TR, Nagengast AK. Siegel TR, et al. Surg Clin North Am. 2019 Oct;99(5):1029-1035. doi: 10.1016/j.suc.2019.06.015. Epub 2019 Jul 31. Surg Clin North Am. 2019. PMID: 31446908 Review.
Individual commitment to self-care in conjunction with support from within health care organizations create the optimal framework in which burnout can be mitigated....
Individual commitment to self-care in conjunction with support from within health care organizations create the optimal framework in …
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
Wang P, Doxtader KA, Nam Y. Wang P, et al. Mol Cell. 2016 Jul 21;63(2):306-317. doi: 10.1016/j.molcel.2016.05.041. Epub 2016 Jun 30. Mol Cell. 2016. PMID: 27373337 Free PMC article.
We present crystal structures of the complex of Mettl3/Mettl14 methyltransferase domains in apo form as well as with bound S-adenosylmethionine (SAM) or S-adenosylhomocysteine (SAH) in the catalytic site. We determine that the heterodimeric complex of methyltransferase dom …
We present crystal structures of the complex of Mettl3/Mettl14 methyltransferase domains in apo form as well as with bound S-adenosylmethion …
Deep Plane Facelift.
Raggio BS, Patel BC. Raggio BS, et al. 2023 Apr 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Apr 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 31424861 Free Books & Documents.
The deep plane facelift, originally described by Sam Hamra in 1990, utilizes a plane of dissection below the superficial muscular aponeurotic system (SMAS) of the midface, allowing for direct lysis of key facial retaining ligaments and maximum mobilization of the superfici …
The deep plane facelift, originally described by Sam Hamra in 1990, utilizes a plane of dissection below the superficial muscular apo …
Leaf development and evolution.
Nikolov LA, Runions A, Das Gupta M, Tsiantis M. Nikolov LA, et al. Curr Top Dev Biol. 2019;131:109-139. doi: 10.1016/bs.ctdb.2018.11.006. Epub 2018 Dec 19. Curr Top Dev Biol. 2019. PMID: 30612614 Review.
These outgrowths are generated by a patterning mechanism similar to the phyllotactic processes producing organs at the SAM, which involves the transcription factors CUP-SHAPED COTYLEDON and the phytohormone auxin. In the leaf, this patterning mechanism creates seque …
These outgrowths are generated by a patterning mechanism similar to the phyllotactic processes producing organs at the SAM, which inv …
DLC1 SAM domain-binding peptides inhibit cancer cell growth and migration by inactivating RhoA.
Joshi R, Qin L, Cao X, Zhong S, Voss C, Min W, Li SSC. Joshi R, et al. J Biol Chem. 2020 Jan 10;295(2):645-656. doi: 10.1074/jbc.RA119.011929. Epub 2019 Dec 5. J Biol Chem. 2020. PMID: 31806702 Free PMC article.
We show here that the TNS3/PTEN-DLC1 interactions are mediated by the C2 domains of the former and the SAM domain of the latter. Intriguingly, the DLC1 SAM domain was capable of binding to specific peptide motifs within the C2 domains. ...Our work shows, for the fir …
We show here that the TNS3/PTEN-DLC1 interactions are mediated by the C2 domains of the former and the SAM domain of the latter. Intr …
The magic of a methyl group: Biochemistry at the service of medicine.
De Clercq E. De Clercq E. Biochem Pharmacol. 2023 Oct;216:115786. doi: 10.1016/j.bcp.2023.115786. Epub 2023 Sep 1. Biochem Pharmacol. 2023. PMID: 37660830 Review.
A carbon-carbon linkage is created when a methyl group is implanted on dUMP, thus resulting in the formation of dTMP by thymidylate synthase. ...The methyl group is rearranged with the help of vitamin B12 in the isomerization of methylmalonyl-CoA to succinyl-CoA. S-adenosy …
A carbon-carbon linkage is created when a methyl group is implanted on dUMP, thus resulting in the formation of dTMP by thymidylate s …
Systolic Anterior Motion (SAM) Complicating Mitral Valve Repair: Current Concepts of Intraoperative and Postoperative Management.
Nenna A, Nappi F, Spadaccio C, Barberi F, Greco SM, Lusini M, Chello M. Nenna A, et al. Surg Technol Int. 2020 Nov 28;37:225-232. Surg Technol Int. 2020. PMID: 32557521 Review.
Awareness of risk factors for SAM influences operative planning for repair. Predictors of SAM are known and can be definitively evaluated with intraoperative transesophageal echocardiography, but SAM still complicates mitral valve repair and, if untreated, ne …
Awareness of risk factors for SAM influences operative planning for repair. Predictors of SAM are known and can be definitivel …
Creating workforce transformation.
Foster S. Foster S. Br J Nurs. 2017 Jul 27;26(14):837. doi: 10.12968/bjon.2017.26.14.837. Br J Nurs. 2017. PMID: 28745969
Sam Foster, Chief Nurse at Heart of England NHS Foundation Trust, looks at opportunities for continuing professional development, which is key for both recruitment and retention....
Sam Foster, Chief Nurse at Heart of England NHS Foundation Trust, looks at opportunities for continuing professional development, whi …
Surgical Management for Systolic Anterior Motion (SAM) of the Mitral Valve in Obstructive Hypertrophic Myopathy.
Usui A, Mutsuga M. Usui A, et al. Ann Thorac Cardiovasc Surg. 2022 Aug 20;28(4):239-248. doi: 10.5761/atcs.ra.22-00103. Epub 2022 Jul 15. Ann Thorac Cardiovasc Surg. 2022. PMID: 35851569 Free PMC article. Review.
In patients with obstructive hypertrophic cardiomyopathy, left ventricular outflow tract (LVOT) obstruction can be created by the hypertrophic interventricular septum (IVS) as well as systolic anterior motion (SAM) of the anterior mitral leaflet (AML). Sufficient se …
In patients with obstructive hypertrophic cardiomyopathy, left ventricular outflow tract (LVOT) obstruction can be created by the hyp …
1,105 results