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Year Number of Results
1856 1
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1921 1
1941 1
1943 1
1945 2
1946 1
1947 1
1948 1
1949 1
1950 2
1951 2
1953 2
1954 2
1955 6
1956 1
1959 2
1961 5
1962 4
1963 28
1964 61
1965 69
1966 125
1967 124
1968 92
1969 48
1970 43
1971 13
1972 12
1973 13
1974 22
1975 18
1976 34
1977 34
1978 39
1979 42
1980 47
1981 43
1982 43
1983 48
1984 47
1985 55
1986 55
1987 107
1988 120
1989 178
1990 177
1991 147
1992 207
1993 194
1994 213
1995 247
1996 218
1997 259
1998 308
1999 291
2000 394
2001 517
2002 625
2003 615
2004 762
2005 944
2006 1020
2007 986
2008 1154
2009 1168
2010 1262
2011 1383
2012 1395
2013 1554
2014 1823
2015 1993
2016 2223
2017 2329
2018 2436
2019 2543
2020 2839
2021 3218
2022 3335
2023 2983
2024 1250

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The following term was not found in PubMed: Betts-Davies
Page 1
The U6 snRNA m(6)A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention.
Pendleton KE, Chen B, Liu K, Hunter OV, Xie Y, Tu BP, Conrad NK. Pendleton KE, et al. Cell. 2017 May 18;169(5):824-835.e14. doi: 10.1016/j.cell.2017.05.003. Cell. 2017. PMID: 28525753 Free PMC article.
Maintenance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for a wide variety of biological processes. We demonstrate that the N(6)-adenosine methyltransferase METTL16 regulates expression of human MAT2A, which encodes the SAM synthetase …
Maintenance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for a wide variety of biological processes. W …
S-Adenosylmethionine: more than just a methyl donor.
Lee YH, Ren D, Jeon B, Liu HW. Lee YH, et al. Nat Prod Rep. 2023 Sep 20;40(9):1521-1549. doi: 10.1039/d2np00086e. Nat Prod Rep. 2023. PMID: 36891755 Free PMC article. Review.
The reaction scope is further expanded as SAM itself can be modified prior to the group transfer such that a SAM-derived carboxymethyl or aminopropyl moiety can also be transferred. Moreover, the sulfonium cation in SAM has itself been found to be critical fo …
The reaction scope is further expanded as SAM itself can be modified prior to the group transfer such that a SAM-derived carbo …
S-Adenosylmethionine.
Lu SC. Lu SC. Int J Biochem Cell Biol. 2000 Apr;32(4):391-5. doi: 10.1016/s1357-2725(99)00139-9. Int J Biochem Cell Biol. 2000. PMID: 10762064 Review.
S-Adenosyl-Lmethionine (SAM) is an important molecule in normal cell function and survival. SAM is utilized by three key metabolic pathways: transmethylation; transsulfuration; and polyamine synthesis. ...
S-Adenosyl-Lmethionine (SAM) is an important molecule in normal cell function and survival. SAM is utilized by three key metab …
Sam Domains in Multiple Diseases.
Vincenzi M, Mercurio FA, Leone M. Vincenzi M, et al. Curr Med Chem. 2020;27(3):450-476. doi: 10.2174/0929867325666181009114445. Curr Med Chem. 2020. PMID: 30306850 Review.
This study intends to collect state-of-the-art knowledge on the different modes by which Sam domains can favor disease onset and progression. METHODS: This review was build up by searching throughout the literature, for: a) the structural properties of Sam domains, …
This study intends to collect state-of-the-art knowledge on the different modes by which Sam domains can favor disease onset and prog …
Technical note: Generalizable and promptable artificial intelligence model to augment clinical delineation in radiation oncology.
Zhang L, Liu Z, Zhang L, Wu Z, Yu X, Holmes J, Feng H, Dai H, Li X, Li Q, Wong WW, Vora SA, Zhu D, Liu T, Liu W. Zhang L, et al. Med Phys. 2024 Mar;51(3):2187-2199. doi: 10.1002/mp.16965. Epub 2024 Feb 6. Med Phys. 2024. PMID: 38319676
SAM's box prompt mode further improves Dice scores by 0.1~0.5. Similar results were observed for Jaccard indices. The results show that SAM performs better for prostate and lung, but worse for gastrointestinal and head & neck. ...
SAM's box prompt mode further improves Dice scores by 0.1~0.5. Similar results were observed for Jaccard indices. The results show th …
Radical SAM enzymes: Nature's choice for radical reactions.
Broderick JB, Broderick WE, Hoffman BM. Broderick JB, et al. FEBS Lett. 2023 Jan;597(1):92-101. doi: 10.1002/1873-3468.14519. Epub 2022 Oct 27. FEBS Lett. 2023. PMID: 36251330 Free PMC article. Review.
Enzymes that use a [4Fe-4S](1+) cluster plus S-adenosyl-l-methionine (SAM) to initiate radical reactions (radical SAM) form the largest enzyme superfamily, with over half a million members across the tree of life. ...The simplicity of SAM as a radical precurs …
Enzymes that use a [4Fe-4S](1+) cluster plus S-adenosyl-l-methionine (SAM) to initiate radical reactions (radical SAM) form th …
[Microbial production of S-adenosyl-l-methionine: a review].
Li M, Mi Z, Wang J, Hu Z, Qin H, Wang Y, Zheng Y. Li M, et al. Sheng Wu Gong Cheng Xue Bao. 2023 Jun 25;39(6):2248-2264. doi: 10.13345/j.cjb.220959. Sheng Wu Gong Cheng Xue Bao. 2023. PMID: 37401593 Free article. Review. Chinese.
With the rapid growth in SAM demand, interests in improving SAM production by developing SAM hyper-producing microorganisms aroused. ...This review summarizes the recent research progress in improving microbial SAM productivity to facilitate further im …
With the rapid growth in SAM demand, interests in improving SAM production by developing SAM hyper-producing microorgan …
Diversity of the reaction mechanisms of SAM-dependent enzymes.
Sun Q, Huang M, Wei Y. Sun Q, et al. Acta Pharm Sin B. 2021 Mar;11(3):632-650. doi: 10.1016/j.apsb.2020.08.011. Epub 2020 Aug 26. Acta Pharm Sin B. 2021. PMID: 33777672 Free PMC article. Review.
Methyltransferases (MTases), a major group of SAM-dependent enzymes, catalyze methyl transfer from SAM to C, O, N, and S atoms in small-molecule secondary metabolites and macromolecules, including proteins and nucleic acids. ...Herein, we mainly describe the nonmeth …
Methyltransferases (MTases), a major group of SAM-dependent enzymes, catalyze methyl transfer from SAM to C, O, N, and S atoms …
The structure of the SAM/SAH-binding riboswitch.
Weickhmann AK, Keller H, Wurm JP, Strebitzer E, Juen MA, Kremser J, Weinberg Z, Kreutz C, Duchardt-Ferner E, Wöhnert J. Weickhmann AK, et al. Nucleic Acids Res. 2019 Mar 18;47(5):2654-2665. doi: 10.1093/nar/gky1283. Nucleic Acids Res. 2019. PMID: 30590743 Free PMC article.
S-adenosylmethionine (SAM) is a central metabolite since it is used as a methyl group donor in many different biochemical reactions. Many bacteria control intracellular SAM concentrations using riboswitch-based mechanisms. A number of structurally different riboswit …
S-adenosylmethionine (SAM) is a central metabolite since it is used as a methyl group donor in many different biochemical reactions. …
Structure-based insights into recognition and regulation of SAM-sensing riboswitches.
Zheng L, Song Q, Xu X, Shen X, Li C, Li H, Chen H, Ren A. Zheng L, et al. Sci China Life Sci. 2023 Jan;66(1):31-50. doi: 10.1007/s11427-022-2188-7. Epub 2022 Nov 29. Sci China Life Sci. 2023. PMID: 36459353 Review.
SAM riboswitch is one of the most abundant riboswitches that bind to SAM with high affinity and selectivity, serving as regulatory modules in multiple metabolic pathways. To date, seven SAM-specific riboswitch classes that belong to four families, one SAM …
SAM riboswitch is one of the most abundant riboswitches that bind to SAM with high affinity and selectivity, serving as regula …
39,959 results
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