Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial

Nutrients. 2020 Mar 24;12(3):861. doi: 10.3390/nu12030861.

Abstract

Abdominal aortic calcification (AAC) detected on lateral vertebral fracture assessment is associated with increased cardiovascular risk. Vitamin D deficiency and toxicity have been linked with vascular calcification. The objective of this study was to determine the effect of high-dose vitamin D on the progression of AAC. The Physical Performance, Osteoporosis and vitamin D in African American Women (PODA) is a randomized, clinical trial examining the effect of vitamin D. There were 14.7% subjects with AAC in the vitamin D group, compared to 12.1% in the placebo group at baseline. The prevalence of extended AAC at baseline was 6.4% in the vitamin D group and 3.5% in the placebo group. The extended calcification scores over time were not different between groups. There was no association between AAC and serum 25(OH)D. However, PTH was associated with an increase in AAC in the placebo group.

Keywords: African American (AA); abdominal aortic calcification (AAC); chronic kidney disease (CKD); dual-energy X-ray absorptiometry (DXA); extended aortic calcification (AAC24); parathyroid hormone; vascular calcification (VC); vertebral fracture assessment (VFA).

MeSH terms

  • Aged
  • Aorta, Abdominal* / pathology
  • Biomarkers
  • Black or African American*
  • Dietary Supplements
  • Disease Susceptibility
  • Female
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Osteoporosis
  • Prevalence
  • Risk Factors
  • Sex Factors
  • Vascular Calcification / epidemiology*
  • Vascular Calcification / etiology*
  • Vascular Calcification / metabolism
  • Vascular Calcification / pathology
  • Vitamin D / administration & dosage*
  • Vitamin D / blood

Substances

  • Biomarkers
  • Vitamin D