Arsenic trioxide targets Hsp60, triggering degradation of p53 and survivin.
Hu X, Li H, Ip TK, Cheung YF, Koohi-Moghadam M, Wang H, Yang X, Tritton DN, Wang Y, Wang Y, Wang R, Ng KM, Naranmandura H, Tse EW, Sun H.
Hu X, et al.
Chem Sci. 2021 Jul 17;12(32):10893-10900. doi: 10.1039/d1sc03119h. eCollection 2021 Aug 18.
Chem Sci. 2021.
PMID: 34476069
Free PMC article.
Herein, we integrate metalloproteomics through a newly developed organoarsenic probe, As-AC (C(20)H(17)AsN(4)O(3)S(2)) with quantitative proteomics, allowing 37 arsenic binding and 250 arsenic regulated proteins to be identified in NB4, a human APL cell line. ...
Herein, we integrate metalloproteomics through a newly developed organoarsenic probe, As-AC (C(20)H(17)AsN(4)O(3)S(2)) with quantitat …