Phenoxydifluoromethyl substituted nitrogen heterocycles. Synthesis and heterocyclization reactions of ethyl 4,4-difluoro- 4-phenoxyacetoacetate

S Yu Solodukhin; A S Peregudov; E V Vorontsov; N D Chkanikov

doi:10.3390/90300164

Phenoxydifluoromethyl substituted nitrogen heterocycles. Synthesis and heterocyclization reactions of ethyl 4,4-difluoro- 4-phenoxyacetoacetate

Molecules. 2004 Feb 28;9(3):164-9. doi: 10.3390/90300164.

Authors

S Yu Solodukhin¹, A S Peregudov, E V Vorontsov, N D Chkanikov

Affiliation

¹ A. N. Nesmeyanov Institute of Organoelement Compounds (INEOS), Russian Academy of Sciences, Vavilov Str. 28, 119991 Moscow, Russia.

Abstract

Ethyl 4,4-difluoro-4-phenoxyacetoacetate was obtained and studied as a precursor to new heterocyclic compounds. 6-Hydroxypyrimidine, 1,3-dihydro-1,5- benzodiazepin-2-one, quinolin-2-one and 6-hydroxypyrazolo[3,4-b]pyridine derivatives containing phenoxydifluoromethyl groups were synthesized. These results make it possible to introduce aryloxydifluoromethyl substituents for the design of biologically active heterocycles.

MeSH terms

Acetoacetates / chemical synthesis*
Acetoacetates / chemistry
Cyclization
Heterocyclic Compounds / chemical synthesis
Heterocyclic Compounds / chemistry*
Nitrogen / chemistry

Substances

Acetoacetates
Heterocyclic Compounds
ethyl 4,4-difluoro- 4-phenoxyacetoacetate
Nitrogen