Lamin B1 as a key modulator of the developing and aging brain.
Koufi FD, Neri I, Ramazzotti G, Rusciano I, Mongiorgi S, Marvi MV, Fazio A, Shin M, Kosodo Y, Cani I, Giorgio E, Cortelli P, Manzoli L, Ratti S.
Koufi FD, et al.
Front Cell Neurosci. 2023 Aug 31;17:1263310. doi: 10.3389/fncel.2023.1263310. eCollection 2023.
Front Cell Neurosci. 2023.
PMID: 37720548
Free PMC article.
Review.
Although lamin B1 has increased levels during the differentiation of the brain cells, during aging these levels drop leading to senescent phenotypes and inciting neurodegenerative disorders such as Alzheimer's and Parkinson's disease. On the other hand, overexpressi …
Although lamin B1 has increased levels during the differentiation of the brain cells, during aging these levels drop leading to senescent ph …