Locking and Unlocking Thrombin Function Using Immunoquiescent Nucleic Acid Nanoparticles with Regulated Retention In Vivo.
Ke W, Chandler M, Cedrone E, Saito RF, Rangel MC, de Souza Junqueira M, Wang J, Shi D, Truong N, Richardson M, Rolband LA, Dréau D, Bedocs P, Chammas R, Dokholyan NV, Dobrovolskaia MA, Afonin KA.
Ke W, et al.
Nano Lett. 2022 Jul 27;22(14):5961-5972. doi: 10.1021/acs.nanolett.2c02019. Epub 2022 Jul 5.
Nano Lett. 2022.
PMID: 35786891
Free PMC article.
To assess interindividual variability, the anticoagulation is confirmed in the blood of human donors from the U.S. and Brazil. The anticoagulant fibers reveal superior anticoagulant activity and prolonged renal clearance in vivo in comparison to free aptamers. ...
To assess interindividual variability, the anticoagulation is confirmed in the blood of human donors from the U.S. and Brazil. The an …