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Increased megalin expression in early type 2 diabetes: role of insulin-signaling pathways.
Bryniarski MA, Yee BM, Jaffri I, Chaves LD, Yu JA, Guan X, Ghavam N, Yacoub R, Morris ME. Bryniarski MA, et al. Am J Physiol Renal Physiol. 2018 Nov 1;315(5):F1191-F1207. doi: 10.1152/ajprenal.00210.2018. Epub 2018 Jun 27. Am J Physiol Renal Physiol. 2018. PMID: 29949391 Free article.

Based on these results, the ability of insulin to increase megalin was examined in a clonal subpopulation of the opossum kidney proximal tubule cell line. Insulin treatments (24 h, 100 nM) under high glucose conditions significantly increased megalin protein ( P < 0.000

Based on these results, the ability of insulin to increase megalin was examined in a clonal subpopulation of the opossum kidney proximal tub …