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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2003 1
2004 2
2005 5
2006 6
2007 6
2008 12
2009 12
2010 6
2011 21
2012 14
2013 15
2014 15
2015 19
2016 18
2017 12
2018 12
2019 6
2020 13
2021 23
2022 15
2023 8
2024 0

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205 results

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Page 1
Cell models for Alzheimer's and Parkinson's disease: At the interface of biology and drug discovery.
Cetin S, Knez D, Gobec S, Kos J, Pišlar A. Cetin S, et al. Biomed Pharmacother. 2022 May;149:112924. doi: 10.1016/j.biopha.2022.112924. Epub 2022 Apr 8. Biomed Pharmacother. 2022. PMID: 36068783 Free article. Review.
Neurodegenerative diseases are severely debilitating conditions characterized primarily by progressive neuronal loss and impairment of the nervous system. Alzheimer's and Parkinson's diseases are the most common neurodegenerative disorders, and their impact is incre …
Neurodegenerative diseases are severely debilitating conditions characterized primarily by progressive neuronal loss and impairment of the n …
Dual inhibitors of cholinesterases and monoamine oxidases for Alzheimer's disease.
Knez D, Sova M, Košak U, Gobec S. Knez D, et al. Future Med Chem. 2017 May;9(8):811-832. doi: 10.4155/fmc-2017-0036. Epub 2017 May 15. Future Med Chem. 2017. PMID: 28504893 Review.
Accumulating evidence indicates a solid relationship between several enzymes and Alzheimer's disease. Cholinesterases and monoamine oxidases are closely associated with the disease symptomatology and progression and have been tackled simultaneously using several multifunct …
Accumulating evidence indicates a solid relationship between several enzymes and Alzheimer's disease. Cholinesterases and monoamine o …
N-alkylpiperidine carbamates as potential anti-Alzheimer's agents.
Košak U, Strašek N, Knez D, Jukič M, Žakelj S, Zahirović A, Pišlar A, Brazzolotto X, Nachon F, Kos J, Gobec S. Košak U, et al. Eur J Med Chem. 2020 Jul 1;197:112282. doi: 10.1016/j.ejmech.2020.112282. Epub 2020 Apr 15. Eur J Med Chem. 2020. PMID: 32380361
Compounds capable of interacting with single or multiple targets involved in Alzheimer's disease (AD) pathogenesis are potential anti-Alzheimer's agents. In our aim to develop new anti-Alzheimer's agents, a series of 36 new N-alkylpiperidine carbamates was de …
Compounds capable of interacting with single or multiple targets involved in Alzheimer's disease (AD) pathogenesis are potential anti …
Methylation of selenocysteine catalysed by thiopurine S-methyltransferase.
Urbančič D, Kotar A, Šmid A, Jukič M, Gobec S, Mårtensson LG, Plavec J, Mlinarič-Raščan I. Urbančič D, et al. Biochim Biophys Acta Gen Subj. 2019 Jan;1863(1):182-190. doi: 10.1016/j.bbagen.2018.10.002. Epub 2018 Oct 9. Biochim Biophys Acta Gen Subj. 2019. PMID: 30308221 Free article.
BACKGROUND: Methylation driven by thiopurine S-methylatransferase (TPMT) is crucial for deactivation of cytostatic and immunosuppressant thiopurines. ...By comparing binding characteristics of Sec in the absence and in the presence of methyl donor, we confirmed S-ad …
BACKGROUND: Methylation driven by thiopurine S-methylatransferase (TPMT) is crucial for deactivation of cytostatic and immunosuppress …
MurD enzymes: some recent developments.
Šink R, Barreteau H, Patin D, Mengin-Lecreulx D, Gobec S, Blanot D. Šink R, et al. Biomol Concepts. 2013 Dec;4(6):539-56. doi: 10.1515/bmc-2013-0024. Biomol Concepts. 2013. PMID: 25436755 Free article. Review.
Inhibitors of aldo-keto reductases AKR1C1-AKR1C4.
Brožič P, Turk S, Rižner TL, Gobec S. Brožič P, et al. Curr Med Chem. 2011;18(17):2554-65. doi: 10.2174/092986711795933713. Curr Med Chem. 2011. PMID: 21568892 Review.
A new 'golden age' for the antitubercular target InhA.
Rožman K, Sosič I, Fernandez R, Young RJ, Mendoza A, Gobec S, Encinas L. Rožman K, et al. Drug Discov Today. 2017 Mar;22(3):492-502. doi: 10.1016/j.drudis.2016.09.009. Epub 2016 Sep 20. Drug Discov Today. 2017. PMID: 27663094 Review.
205 results