Light chain of a public SARS-CoV-2 class-3 antibody modulates neutralization against Omicron.
Patel A, Kumar S, Lai L, Keen M, Valanparambil R, Chakravarthy C, Laughlin Z, Frank F, Cheedarla N, Verkerke HP, Neish AS, Roback JD, Davis CW, Wrammert J, Sharma A, Ahmed R, Suthar MS, Murali-Krishna K, Chandele A, Ortlund E.
Patel A, et al.
Cell Rep. 2023 Sep 26;42(9):113150. doi: 10.1016/j.celrep.2023.113150. Epub 2023 Sep 13.
Cell Rep. 2023.
PMID: 37708028
Free PMC article.
Confirming this, replacing the light chain of 002-S21B10 with the light chain of LY-CoV1404 restored 002-S21B10's binding to Omicron. Understanding such Omicron evasion from public response is vital for guiding therapeutics and vaccine design....
Confirming this, replacing the light chain of 002-S21B10 with the light chain of LY-CoV1404 restored 002-S21B10's binding to Omicron. …