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N-Methylation as a Strategy for Enhancing the Affinity and Selectivity of RNA-binding Peptides: Application to the HIV-1 Frameshift-Stimulating RNA.
Hilimire TA, Bennett RP, Stewart RA, Garcia-Miranda P, Blume A, Becker J, Sherer N, Helms ED, Butcher SE, Smith HC, Miller BL. Hilimire TA, et al. Among authors: stewart ra. ACS Chem Biol. 2016 Jan 15;11(1):88-94. doi: 10.1021/acschembio.5b00682. Epub 2015 Nov 3. ACS Chem Biol. 2016. PMID: 26496521 Free PMC article.
HIV-1 Frameshift RNA-Targeted Triazoles Inhibit Propagation of Replication-Competent and Multi-Drug-Resistant HIV in Human Cells.
Hilimire TA, Chamberlain JM, Anokhina V, Bennett RP, Swart O, Myers JR, Ashton JM, Stewart RA, Featherston AL, Gates K, Helms ED, Smith HC, Dewhurst S, Miller BL. Hilimire TA, et al. Among authors: stewart ra. ACS Chem Biol. 2017 Jun 16;12(6):1674-1682. doi: 10.1021/acschembio.7b00052. Epub 2017 May 5. ACS Chem Biol. 2017. PMID: 28448121 Free PMC article.
An analog of camptothecin inactive against Topoisomerase I is broadly neutralizing of HIV-1 through inhibition of Vif-dependent APOBEC3G degradation.
Bennett RP, Stewart RA, Hogan PA, Ptak RG, Mankowski MK, Hartman TL, Buckheit RW Jr, Snyder BA, Salter JD, Morales GA, Smith HC. Bennett RP, et al. Among authors: stewart ra. Antiviral Res. 2016 Dec;136:51-59. doi: 10.1016/j.antiviral.2016.11.001. Epub 2016 Nov 5. Antiviral Res. 2016. PMID: 27825797 Free PMC article.