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Showing results for ruth marrow
Search for Ruth Morrow instead (3 results)
The bone marrow microenvironment at single-cell resolution.
Tikhonova AN, Dolgalev I, Hu H, Sivaraj KK, Hoxha E, Cuesta-Domínguez Á, Pinho S, Akhmetzyanova I, Gao J, Witkowski M, Guillamot M, Gutkin MC, Zhang Y, Marier C, Diefenbach C, Kousteni S, Heguy A, Zhong H, Fooksman DR, Butler JM, Economides A, Frenette PS, Adams RH, Satija R, Tsirigos A, Aifantis I. Tikhonova AN, et al. Nature. 2019 May;569(7755):222-228. doi: 10.1038/s41586-019-1104-8. Epub 2019 Apr 10. Nature. 2019. PMID: 30971824 Free PMC article.
The bone marrow microenvironment has a key role in regulating haematopoiesis, but its molecular complexity and response to stress are incompletely understood. Here we map the transcriptional landscape of mouse bone marrow vascular, perivascular and ost …
The bone marrow microenvironment has a key role in regulating haematopoiesis, but its molecular complexity and response to str …
Haematopoietic stem cell activity and interactions with the niche.
Pinho S, Frenette PS. Pinho S, et al. Nat Rev Mol Cell Biol. 2019 May;20(5):303-320. doi: 10.1038/s41580-019-0103-9. Nat Rev Mol Cell Biol. 2019. PMID: 30745579 Free PMC article. Review.
The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal, differentiation and migration of HSCs and progenitor cells at steady state and in response to …
The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the niche, ensures haematopoietic homeostasis b …
Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche.
Maryanovich M, Zahalka AH, Pierce H, Pinho S, Nakahara F, Asada N, Wei Q, Wang X, Ciero P, Xu J, Leftin A, Frenette PS. Maryanovich M, et al. Nat Med. 2018 Jun;24(6):782-791. doi: 10.1038/s41591-018-0030-x. Epub 2018 May 7. Nat Med. 2018. PMID: 29736022 Free PMC article.
Aging of hematopoietic stem cells (HSCs) is associated with a decline in their regenerative capacity and multilineage differentiation potential, contributing to the development of blood disorders. The bone marrow microenvironment has recently been suggested to influ …
Aging of hematopoietic stem cells (HSCs) is associated with a decline in their regenerative capacity and multilineage differentiation potent …
The hematopoietic stem cell niche: from embryo to adult.
Gao X, Xu C, Asada N, Frenette PS. Gao X, et al. Development. 2018 Jan 22;145(2):dev139691. doi: 10.1242/dev.139691. Development. 2018. PMID: 29358215 Free PMC article. Review.
However, controversy exists concerning the cellular complexity of the bone marrow niche, and our understanding of the different HSC niches during development remains limited. In this Review, we summarize and discuss what is known about the heterogeneity of the HSC n …
However, controversy exists concerning the cellular complexity of the bone marrow niche, and our understanding of the differen …
The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow.
Zhang D, Gao X, Li H, Borger DK, Wei Q, Yang E, Xu C, Pinho S, Frenette PS. Zhang D, et al. Cell Stem Cell. 2022 Feb 3;29(2):232-247.e7. doi: 10.1016/j.stem.2021.12.009. Epub 2022 Jan 21. Cell Stem Cell. 2022. PMID: 35065706 Free PMC article.
Here, we show that the microbiota regulates HSC self-renewal and differentiation under stress conditions by modulating local iron availability in the bone marrow (BM). In microbiota-depleted mice, HSC self-renewal was enhanced during regeneration, while the commitme …
Here, we show that the microbiota regulates HSC self-renewal and differentiation under stress conditions by modulating local iron availabili …
Brain motor and fear circuits regulate leukocytes during acute stress.
Poller WC, Downey J, Mooslechner AA, Khan N, Li L, Chan CT, McAlpine CS, Xu C, Kahles F, He S, Janssen H, Mindur JE, Singh S, Kiss MG, Alonso-Herranz L, Iwamoto Y, Kohler RH, Wong LP, Chetal K, Russo SJ, Sadreyev RI, Weissleder R, Nahrendorf M, Frenette PS, Divangahi M, Swirski FK. Poller WC, et al. Nature. 2022 Jul;607(7919):578-584. doi: 10.1038/s41586-022-04890-z. Epub 2022 May 30. Nature. 2022. PMID: 35636458 Free PMC article.
Using optogenetics and chemogenetics, we demonstrate that motor circuits induce rapid neutrophil mobilization from the bone marrow to peripheral tissues through skeletal-muscle-derived neutrophil-attracting chemokines. Conversely, the paraventricular hypothalamus co …
Using optogenetics and chemogenetics, we demonstrate that motor circuits induce rapid neutrophil mobilization from the bone marrow …
Nociceptive nerves regulate haematopoietic stem cell mobilization.
Gao X, Zhang D, Xu C, Li H, Caron KM, Frenette PS. Gao X, et al. Nature. 2021 Jan;589(7843):591-596. doi: 10.1038/s41586-020-03057-y. Epub 2020 Dec 23. Nature. 2021. PMID: 33361809 Free PMC article.
Haematopoietic stem cells (HSCs) reside in specialized microenvironments in the bone marrow-often referred to as 'niches'-that represent complex regulatory milieux influenced by multiple cellular constituents, including nerves(1,2). Although sympathetic nerves are k …
Haematopoietic stem cells (HSCs) reside in specialized microenvironments in the bone marrow-often referred to as 'niches'-that …
Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging.
Bogeska R, Mikecin AM, Kaschutnig P, Fawaz M, Büchler-Schäff M, Le D, Ganuza M, Vollmer A, Paffenholz SV, Asada N, Rodriguez-Correa E, Frauhammer F, Buettner F, Ball M, Knoch J, Stäble S, Walter D, Petri A, Carreño-Gonzalez MJ, Wagner V, Brors B, Haas S, Lipka DB, Essers MAG, Weru V, Holland-Letz T, Mallm JP, Rippe K, Krämer S, Schlesner M, McKinney Freeman S, Florian MC, King KY, Frenette PS, Rieger MA, Milsom MD. Bogeska R, et al. Cell Stem Cell. 2022 Aug 4;29(8):1273-1284.e8. doi: 10.1016/j.stem.2022.06.012. Epub 2022 Jul 19. Cell Stem Cell. 2022. PMID: 35858618 Free PMC article.
HSCs from challenged mice demonstrated multiple cellular and molecular features of accelerated aging and developed clinically relevant blood and bone marrow phenotypes not normally observed in aged laboratory mice but commonly seen in elderly humans. ...
HSCs from challenged mice demonstrated multiple cellular and molecular features of accelerated aging and developed clinically relevant blood …
Neutrophil ageing is regulated by the microbiome.
Zhang D, Chen G, Manwani D, Mortha A, Xu C, Faith JJ, Burk RD, Kunisaki Y, Jang JE, Scheiermann C, Merad M, Frenette PS. Zhang D, et al. Nature. 2015 Sep 24;525(7570):528-32. doi: 10.1038/nature15367. Epub 2015 Sep 16. Nature. 2015. PMID: 26374999 Free PMC article.
Under steady-state conditions, neutrophil heterogeneity may arise from ageing and replenishment by newly released neutrophils from the bone marrow. Aged neutrophils upregulate CXCR4, a receptor allowing their clearance in the bone marrow, with feedback …
Under steady-state conditions, neutrophil heterogeneity may arise from ageing and replenishment by newly released neutrophils from the bo …
Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool.
Jordan S, Tung N, Casanova-Acebes M, Chang C, Cantoni C, Zhang D, Wirtz TH, Naik S, Rose SA, Brocker CN, Gainullina A, Hornburg D, Horng S, Maier BB, Cravedi P, LeRoith D, Gonzalez FJ, Meissner F, Ochando J, Rahman A, Chipuk JE, Artyomov MN, Frenette PS, Piccio L, Berres ML, Gallagher EJ, Merad M. Jordan S, et al. Cell. 2019 Aug 22;178(5):1102-1114.e17. doi: 10.1016/j.cell.2019.07.050. Cell. 2019. PMID: 31442403 Free PMC article.
Specifically, we found that activation of the low-energy sensor 5'-AMP-activated protein kinase (AMPK) in hepatocytes and suppression of systemic CCL2 production by peroxisome proliferator-activator receptor alpha (PPARalpha) reduced monocyte mobilization from the bone …
Specifically, we found that activation of the low-energy sensor 5'-AMP-activated protein kinase (AMPK) in hepatocytes and suppression of sys …
266 results