New Polyketides from the Marine-Derived Fungus Letendraea sp. 5XNZ4-2

Mar Drugs. 2019 Dec 24;18(1):18. doi: 10.3390/md18010018.

Abstract

Marine-derived fungi have been reported to have great potential to produce structurally unique metabolites. Our investigation on secondary metabolites from marine-derived fungi resulted in the isolation of seven new polyketides (phomopsiketones D-G (1-4) and letendronols A-C (5-7)) as well as one known xylarinol (8) in the cultural broth of Letendraea sp. Their structures and absolute configurations were elucidated using a set of spectroscopic and chemical methods, including HRESIMS, NMR, single-crystal X-ray diffraction, ECD calculation, and a modified version of Mosher's method. Compound 2 showed weak inhibition against nitric oxide production in lipopolysaccaride-activated macrophages with an IC50 value of 86 μM.

Keywords: Letendraea sp.; letendronol; marine-derived fungus; phomopsiketone; polyketide.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Ascomycota / chemistry*
  • Cell Line, Tumor / drug effects
  • Crystallography, X-Ray
  • Decapoda / microbiology
  • Gram-Negative Bacteria / drug effects
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Oceans and Seas
  • Polyketides / chemistry*
  • Polyketides / isolation & purification*
  • Polyketides / pharmacology
  • RAW 264.7 Cells

Substances

  • Anti-Bacterial Agents
  • Polyketides