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Erythropoietin improves skeletal muscle microcirculation and tissue bioenergetics in a mouse sepsis model.
Kao R, Xenocostas A, Rui T, Yu P, Huang W, Rose J, Martin CM. Kao R, et al. Crit Care. 2007;11(3):R58. doi: 10.1186/cc5920. Crit Care. 2007. PMID: 17509156 Free PMC article.
A significant increase in baseline NADH, suggesting tissue hypoxia, was noted in the CLP mice compared to the sham group (48.3 versus 43.9 fluorescence units [FU]; p = 0.03) and improved with rHuEPO from 48.3 to 44.4 FU at 40 minutes (p = 0.02). Six hours after trea …
A significant increase in baseline NADH, suggesting tissue hypoxia, was noted in the CLP mice compared to the sham group (48.3 versus 43.9 f …