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Multimerin-2 maintains vascular stability and permeability.
Pellicani R, Poletto E, Andreuzzi E, Paulitti A, Doliana R, Bizzotto D, Braghetta P, Colladel R, Tarticchio G, Sabatelli P, Bucciotti F, Bressan G, Iozzo RV, Colombatti A, Bonaldo P, Mongiat M. Pellicani R, et al. Matrix Biol. 2020 May;87:11-25. doi: 10.1016/j.matbio.2019.08.002. Epub 2019 Aug 15. Matrix Biol. 2020. PMID: 31422156 Free article.
Multimerin-2 orchestrates the cross-talk between endothelial cells and pericytes: A mechanism to maintain vascular stability.
Fejza A, Poletto E, Carobolante G, Camicia L, Andreuzzi E, Capuano A, Pivetta E, Pellicani R, Colladel R, Marastoni S, Doliana R, Iozzo RV, Spessotto P, Mongiat M. Fejza A, et al. Among authors: pellicani r. Matrix Biol Plus. 2021 May 28;11:100068. doi: 10.1016/j.mbplus.2021.100068. eCollection 2021 Aug. Matrix Biol Plus. 2021. PMID: 34435184 Free PMC article.
Deregulated expression of Elastin Microfibril Interfacer 2 (EMILIN2) in gastric cancer affects tumor growth and angiogenesis.
Andreuzzi E, Fejza A, Capuano A, Poletto E, Pivetta E, Doliana R, Pellicani R, Favero A, Maiero S, Fornasarig M, Cannizzaro R, Iozzo RV, Spessotto P, Mongiat M. Andreuzzi E, et al. Among authors: pellicani r. Matrix Biol Plus. 2020 Feb 19;6-7:100029. doi: 10.1016/j.mbplus.2020.100029. eCollection 2020 May. Matrix Biol Plus. 2020. PMID: 33543026 Free PMC article.
The angiostatic molecule Multimerin 2 is processed by MMP-9 to allow sprouting angiogenesis.
Andreuzzi E, Colladel R, Pellicani R, Tarticchio G, Cannizzaro R, Spessotto P, Bussolati B, Brossa A, De Paoli P, Canzonieri V, Iozzo RV, Colombatti A, Mongiat M. Andreuzzi E, et al. Among authors: pellicani r. Matrix Biol. 2017 Dec;64:40-53. doi: 10.1016/j.matbio.2017.04.002. Epub 2017 Apr 21. Matrix Biol. 2017. PMID: 28435016 Free article.
The ablation of the matricellular protein EMILIN2 causes defective vascularization due to impaired EGFR-dependent IL-8 production affecting tumor growth.
Paulitti A, Andreuzzi E, Bizzotto D, Pellicani R, Tarticchio G, Marastoni S, Pastrello C, Jurisica I, Ligresti G, Bucciotti F, Doliana R, Colladel R, Braghetta P, Poletto E, Di Silvestre A, Bressan G, Colombatti A, Bonaldo P, Mongiat M. Paulitti A, et al. Among authors: pellicani r. Oncogene. 2018 Jun;37(25):3399-3414. doi: 10.1038/s41388-017-0107-x. Epub 2018 Feb 27. Oncogene. 2018. PMID: 29483644