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2020 2
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Page 1
Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease.
Brunetti L, Leuci R, Carrieri A, Catto M, Occhineri S, Vinci G, Gambacorta L, Baltrukevich H, Chaves S, Laghezza A, Altomare CD, Tortorella P, Santos MA, Loiodice F, Piemontese L. Brunetti L, et al. Among authors: leuci r. Eur J Med Chem. 2022 Jul 5;237:114358. doi: 10.1016/j.ejmech.2022.114358. Epub 2022 Apr 14. Eur J Med Chem. 2022. PMID: 35462163
A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity.
Sblano S, Cerchia C, Laghezza A, Piemontese L, Brunetti L, Leuci R, Gilardi F, Thomas A, Genovese M, Santi A, Tortorella P, Paoli P, Lavecchia A, Loiodice F. Sblano S, et al. Among authors: leuci r. Eur J Med Chem. 2022 May 5;235:114240. doi: 10.1016/j.ejmech.2022.114240. Epub 2022 Mar 16. Eur J Med Chem. 2022. PMID: 35325635
Novel Phenothiazine/Donepezil-like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer's Disease.
Carocci A, Barbarossa A, Leuci R, Carrieri A, Brunetti L, Laghezza A, Catto M, Limongelli F, Chaves S, Tortorella P, Altomare CD, Santos MA, Loiodice F, Piemontese L. Carocci A, et al. Among authors: leuci r. Antioxidants (Basel). 2022 Aug 23;11(9):1631. doi: 10.3390/antiox11091631. Antioxidants (Basel). 2022. PMID: 36139705 Free PMC article.
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition.
Laghezza A, Cerchia C, Genovese M, Leuci R, Pranzini E, Santi A, Brunetti L, Piemontese L, Tortorella P, Biswas A, Singh RP, Tambe S, Ca S, Pattnaik AK, Jayaprakash V, Paoli P, Lavecchia A, Loiodice F. Laghezza A, et al. Among authors: leuci r. J Med Chem. 2023 Mar 9;66(5):3566-3587. doi: 10.1021/acs.jmedchem.2c02093. Epub 2023 Feb 15. J Med Chem. 2023. PMID: 36790935