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Dexmedetomidine compared to low-dose ketamine better protected not only the brain but also the lungs in acute ischemic stroke.
Heil LBB, Braga CL, Magalhães RF, Antunes MA, Cruz FF, Samary CS, Battaglini D, Robba C, Pelosi P, Silva PL, Rocco PRM. Heil LBB, et al. Int Immunopharmacol. 2023 Nov;124(Pt B):111004. doi: 10.1016/j.intimp.2023.111004. Epub 2023 Sep 29. Int Immunopharmacol. 2023. PMID: 37778171
BACKGROUND: Dexmedetomidine (DEX) and low-dose ketamine (KET) present neuroprotective effects in acute ischemic stroke (AIS); however, to date, no studies have evaluated which has better protective effects not only on the brain but also lungs in AIS. METHODS: AIS-induced W …
BACKGROUND: Dexmedetomidine (DEX) and low-dose ketamine (KET) present neuroprotective effects in acute ischemic stroke (AIS); however …
Year in review in Intensive Care Medicine 2012: III. Noninvasive ventilation, monitoring and patient-ventilator interactions, acute respiratory distress syndrome, sedation, paediatrics and miscellanea.
Antonelli M, Bonten M, Cecconi M, Chastre J, Citerio G, Conti G, Curtis JR, Hedenstierna G, Joannidis M, Macrae D, Maggiore SM, Mancebo J, Mebazaa A, Preiser JC, Rocco P, Timsit JF, Wernerman J, Zhang H. Antonelli M, et al. Intensive Care Med. 2013 Apr;39(4):543-57. doi: 10.1007/s00134-012-2807-6. Epub 2013 Jan 22. Intensive Care Med. 2013. PMID: 23338570 Free PMC article. Review. No abstract available.
Dexmedetomidine Sedation After Tracheal Surgery: A Prospective Pilot Study.
Fiorelli S, Creazzola F, Massullo D, Defraia V, Maggi L, Rocco M, Rendina EA. Fiorelli S, et al. Ann Thorac Surg. 2019 Jul;108(1):256-261. doi: 10.1016/j.athoracsur.2019.01.047. Epub 2019 Mar 1. Ann Thorac Surg. 2019. PMID: 30831108
BACKGROUND: Fourteen adults undergoing tracheal resection and reconstruction surgery were enrolled in this prospective observational pilot study to evaluate dexmedetomidine-based sedation after tracheal surgery in an intensive care unit. ...No cases of delirium were encoun …
BACKGROUND: Fourteen adults undergoing tracheal resection and reconstruction surgery were enrolled in this prospective observational pilot s …
Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke.
Battaglini D, da Silva AL, Felix NS, Rodrigues G, Antunes MA, Rocha NN, Capelozzi VL, Morales MM, Cruz FF, Robba C, Silva PL, Pelosi P, Rocco PRM. Battaglini D, et al. Intensive Care Med Exp. 2022 Dec 19;10(1):53. doi: 10.1186/s40635-022-00481-4. Intensive Care Med Exp. 2022. PMID: 36529842 Free PMC article.
In lungs: (1) hypothermia + propofol compared to normothermia + propofol reduced TNF-alpha and histologic injury score; (2) hypothermia + dexmedetomidine compared to normothermia + dexmedetomidine reduced histologic injury score. In kidneys: (1) hypothermia + dex …
In lungs: (1) hypothermia + propofol compared to normothermia + propofol reduced TNF-alpha and histologic injury score; (2) hypothermia + …
Comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke.
Sousa GC, Fernandes MV, Cruz FF, Antunes MA, da Silva CM, Takyia C, Battaglini D, Samary CS, Robba C, Pelosi P, Rocco PRM, Silva PL. Sousa GC, et al. Sci Rep. 2021 Nov 30;11(1):23133. doi: 10.1038/s41598-021-02608-1. Sci Rep. 2021. PMID: 34848804 Free PMC article.
However, it is unknown the immunomodulatory actions of dexmedetomidine and propofol on brain and lungs during acute ischemic stroke. ...Dexmedetomidine, but not propofol, induced brain and lung protection in experimental acute ischemic stroke....
However, it is unknown the immunomodulatory actions of dexmedetomidine and propofol on brain and lungs during acute ischemic stroke. …
Intraoperative opioid exposure, tumour genomic alterations, and survival differences in people with lung adenocarcinoma.
Connolly JG, Tan KS, Mastrogiacomo B, Dycoco J, Caso R, Jones GD, McCormick PJ, Sanchez-Vega F, Irie T, Scarpa JR, Gupta HV, Adusumilli PS, Rocco G, Isbell JM, Bott MJ, Fischer GW, Jones DR, Mincer JS. Connolly JG, et al. Br J Anaesth. 2021 Jul;127(1):75-84. doi: 10.1016/j.bja.2021.03.030. Br J Anaesth. 2021. PMID: 34147159 Free PMC article.
We sought to determine whether intraoperative opioid exposure is associated with recurrence-specific survival and overall survival in early-stage lung adenocarcinoma, and whether selected tumour genomics are associated with this relationship. Associations between ketamine and …
We sought to determine whether intraoperative opioid exposure is associated with recurrence-specific survival and overall survival in early- …
The Effects of Short-Term Propofol and Dexmedetomidine on Lung Mechanics, Histology, and Biological Markers in Experimental Obesity.
Heil LB, Santos CL, Santos RS, Samary CS, Cavalcanti VC, Araújo MM, Poggio H, Maia Lde A, Trevenzoli IH, Pelosi P, Fernandes FC, Villela NR, Silva PL, Rocco PR. Heil LB, et al. Anesth Analg. 2016 Apr;122(4):1015-23. doi: 10.1213/ANE.0000000000001114. Anesth Analg. 2016. PMID: 26720616
In a model of diet-induced obesity, we compared the short-term effects of dexmedetomidine versus propofol on lung mechanics and histology, as well as biological markers of inflammation and oxidative stress modulation in obesity. ...However, unlike sodium thiopental and pro …
In a model of diet-induced obesity, we compared the short-term effects of dexmedetomidine versus propofol on lung mechanics and histo …
Effects of dexmedetomidine on respiratory mechanics and control of breathing in normal rats.
Fernandes FC, Ferreira HC, Cagido VR, Carvalho GM, Pereira LS, Faffe DS, Zin WA, Rocco PR. Fernandes FC, et al. Respir Physiol Neurobiol. 2006 Dec;154(3):342-50. doi: 10.1016/j.resp.2006.02.002. Epub 2006 Mar 9. Respir Physiol Neurobiol. 2006. PMID: 16527548
Dexmedetomidine is a highly selective and specific alpha(2)-adrenergic agonist, with sedative, analgesic, and sympatholytic activities. ...In spontaneously breathing rats, minute ventilation, respiratory frequency, and neuromuscular inspiratory drive were lower in dexme …
Dexmedetomidine is a highly selective and specific alpha(2)-adrenergic agonist, with sedative, analgesic, and sympatholytic activitie …
Effects of short-term propofol and dexmedetomidine on pulmonary morphofunction and biological markers in experimental mild acute lung injury.
Cavalcanti V, Santos CL, Samary CS, Araújo MN, Heil LB, Morales MM, Silva PL, Pelosi P, Fernandes FC, Villela N, Rocco PR. Cavalcanti V, et al. Respir Physiol Neurobiol. 2014 Nov 1;203:45-50. doi: 10.1016/j.resp.2014.08.008. Epub 2014 Aug 19. Respir Physiol Neurobiol. 2014. PMID: 25149586 Free article.
We evaluated whether the short-term use of dexmedetomidine and propofol may attenuate inflammatory response and improve lung morphofunction in experimental acute lung injury (ALI). ...Dexmedetomidine improved oxygenation, but did not modify lung mechanics or histolo …
We evaluated whether the short-term use of dexmedetomidine and propofol may attenuate inflammatory response and improve lung morphofu …