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TAF1 bromodomain inhibition as a candidate epigenetic driver of congenital heart disease.
Biochim Biophys Acta Mol Basis Dis. 2023 Jun;1869(5):166689. doi: 10.1016/j.bbadis.2023.166689. Epub 2023 Mar 21.
Biochim Biophys Acta Mol Basis Dis. 2023.
PMID: 36958711
Free article.
Cholecystokinin peptide signaling is regulated by a TBX5-MEF2 axis in the heart.
Leigh RS, Ruskoaho HJ, Kaynak BL.
Leigh RS, et al.
Peptides. 2021 Feb;136:170459. doi: 10.1016/j.peptides.2020.170459. Epub 2020 Nov 26.
Peptides. 2021.
PMID: 33249116
Free article.
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GATA-targeted compounds modulate cardiac subtype cell differentiation in dual reporter stem cell line.
Välimäki MJ, Leigh RS, Kinnunen SM, March AR, de Sande AH, Kinnunen M, Varjosalo M, Heinäniemi M, Kaynak BL, Ruskoaho H.
Välimäki MJ, et al. Among authors: leigh rs.
Stem Cell Res Ther. 2021 Mar 18;12(1):190. doi: 10.1186/s13287-021-02259-z.
Stem Cell Res Ther. 2021.
PMID: 33736688
Free PMC article.
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Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds.
Karhu ST, Välimäki MJ, Jumppanen M, Kinnunen SM, Pohjolainen L, Leigh RS, Auno S, Földes G, Boije Af Gennäs G, Yli-Kauhaluoma J, Ruskoaho H, Talman V.
Karhu ST, et al. Among authors: leigh rs.
Arch Toxicol. 2018 Sep;92(9):2897-2911. doi: 10.1007/s00204-018-2257-1. Epub 2018 Jul 9.
Arch Toxicol. 2018.
PMID: 29987409
Free PMC article.
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A novel dual reporter embryonic stem cell line for toxicological assessment of teratogen-induced perturbation of anterior-posterior patterning of the heart.
Leigh RS, Ruskoaho HJ, Kaynak BL.
Leigh RS, et al.
Arch Toxicol. 2020 Feb;94(2):631-645. doi: 10.1007/s00204-019-02632-1. Epub 2019 Dec 6.
Arch Toxicol. 2020.
PMID: 31811323
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