POGZ promotes homology-directed DNA repair in an HP1-dependent manner.
Heath J, Cheyou ES, Findlay S, Luo VM, Carpio EP, Lee J, Djerir B, Chen X, Morin T, Lebeau B, Karam M, Bagci H, Grapton D, Ursini-Siegel J, Côté JF, Witcher M, Richard S, Maréchal A, Orthwein A.
Heath J, et al. Among authors: richard s.
EMBO Rep. 2022 Jan 5;23(1):e51041. doi: 10.15252/embr.202051041. Epub 2021 Nov 10.
EMBO Rep. 2022.
PMID: 34758190
Free PMC article.
The heterochromatin protein HP1 plays a central role in the maintenance of genome stability but little is known about how HP1 is controlled. Here, we show that the zinc finger protein POGZ promotes the presence of HP1 at DNA double-strand breaks (DSBs) in human cells. ...
The heterochromatin protein HP1 plays a central role in the maintenance of genome stability but little is known about how HP1 is cont …