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Neuronal Reprogramming for Brain Repair: Challenges and Perspectives.
Bocchi R, Götz M. Bocchi R, et al. Trends Mol Med. 2020 Oct;26(10):890-892. doi: 10.1016/j.molmed.2020.08.006. Epub 2020 Sep 14. Trends Mol Med. 2020. PMID: 32943322 Free article. Review.
Direct reprogramming of local glial cells into neurons is a promising strategy for neuronal replacement in vivo. We discuss recent advances and future challenges in this approach to brain repair....
Direct reprogramming of local glial cells into neurons is a promising strategy for neuronal replacement in vivo. We discuss recent ad …
Nanoheterostructures (NHS) and Their Applications in Nanomedicine: Focusing on In Vivo Studies.
Quarta A, Piccirillo C, Mandriota G, Di Corato R. Quarta A, et al. Materials (Basel). 2019 Jan 3;12(1):139. doi: 10.3390/ma12010139. Materials (Basel). 2019. PMID: 30609839 Free PMC article. Review.
This review reports on the latest development in the synthesis of advanced NHS for biomedicine and on the tests of their functional properties in in vivo studies. The literature discussed here focuses on the diagnostic and therapeutic applications with special emphasis on …
This review reports on the latest development in the synthesis of advanced NHS for biomedicine and on the tests of their functional properti …
Current status and perspectives in split liver transplantation.
Lauterio A, Di Sandro S, Concone G, De Carlis R, Giacomoni A, De Carlis L. Lauterio A, et al. World J Gastroenterol. 2015 Oct 21;21(39):11003-15. doi: 10.3748/wjg.v21.i39.11003. World J Gastroenterol. 2015. PMID: 26494957 Free PMC article. Review.
Nesfatin-1 decreases the motivational and rewarding value of food.
Dore R, Krotenko R, Reising JP, Murru L, Sundaram SM, Di Spiezio A, Müller-Fielitz H, Schwaninger M, Jöhren O, Mittag J, Passafaro M, Shanabrough M, Horvath TL, Schulz C, Lehnert H. Dore R, et al. Neuropsychopharmacology. 2020 Sep;45(10):1645-1655. doi: 10.1038/s41386-020-0682-3. Epub 2020 Apr 30. Neuropsychopharmacology. 2020. PMID: 32353862 Free PMC article.
We here report that both dopamine and GABA neurons express NUCB2/nesfatin-1 in the VTA. Ex vivo electrophysiological recordings show that nesfatin-1 hyperpolarizes dopamine, but not GABA, neurons of the VTA by inducing an outward potassium current. In vivo, central …
We here report that both dopamine and GABA neurons express NUCB2/nesfatin-1 in the VTA. Ex vivo electrophysiological recordings show …
Neurotoxicity in complex environmental mixtures-a case-study at River Danube in Novi Sad (Serbia) using zebrafish embryos.
Massei R, Brack W, Seidensticker S, Hollert H, Muz M, Schulze T, Krauss M, Küster E. Massei R, et al. Environ Sci Pollut Res Int. 2023 Sep;30(42):96138-96146. doi: 10.1007/s11356-023-29186-1. Epub 2023 Aug 11. Environ Sci Pollut Res Int. 2023. PMID: 37566323 Free PMC article.
It has been shown that mixture effects and oxidative stress may jeopardize the application of in vivo assays for the identification of AChE inhibitors in the environment. To confirm that in vivo AChE assays can be successfully applied when dealing with complex mixtu …
It has been shown that mixture effects and oxidative stress may jeopardize the application of in vivo assays for the identification o …
The Phosphatidyl-myo-Inositol Dimannoside Acyltransferase PatA Is Essential for Mycobacterium tuberculosis Growth In Vitro and In Vivo.
Boldrin F, Anso I, Alebouyeh S, Sevilla IA, Geijo M, Garrido JM, Marina A, Cioetto Mazzabò L, Segafreddo G, Guerin ME, Manganelli R, Prados-Rosales R. Boldrin F, et al. J Bacteriol. 2021 Mar 8;203(7):e00439-20. doi: 10.1128/JB.00439-20. Print 2021 Mar 8. J Bacteriol. 2021. PMID: 33468587 Free PMC article.
Here, we focus on PatA, a membrane-associated acyltransferase that transfers a palmitoyl moiety from palmitoyl coenzyme A (palmitoyl-CoA) to the 6-position of the mannose ring linked to the 2-position of inositol in PIM(1)/PIM(2) We validate that the function of PatA is vital for …
Here, we focus on PatA, a membrane-associated acyltransferase that transfers a palmitoyl moiety from palmitoyl coenzyme A (palmitoyl-CoA) to …
A Novel Antibody-IL15 Fusion Protein Selectively Localizes to Tumors, Synergizes with TNF-based Immunocytokine, and Inhibits Metastasis.
Corbellari R, Stringhini M, Mock J, Ongaro T, Villa A, Neri D, De Luca R. Corbellari R, et al. Mol Cancer Ther. 2021 May;20(5):859-871. doi: 10.1158/1535-7163.MCT-20-0853. Epub 2021 Feb 25. Mol Cancer Ther. 2021. PMID: 33632875 Free PMC article.
Unlike previously described fusions of the F8 antibody with human IL15, F8-F8-IL15 and F8-F8-SD-IL15 exhibited a preferential uptake in solid tumors, as evidenced by quantitative biodistribution analysis with radioiodinated protein preparations. Both products were potently active …
Unlike previously described fusions of the F8 antibody with human IL15, F8-F8-IL15 and F8-F8-SD-IL15 exhibited a preferential uptake in soli …
Phosphorylation of histone H2AX in the mouse brain from development to senescence.
Barral S, Beltramo R, Salio C, Aimar P, Lossi L, Merighi A. Barral S, et al. Int J Mol Sci. 2014 Jan 21;15(1):1554-73. doi: 10.3390/ijms15011554. Int J Mol Sci. 2014. PMID: 24451138 Free PMC article.
Phosphorylation of the histone H2AX (gammaH2AX form) is an early response to DNA damage and a marker of aging and disease in several cells and tissues outside the nervous system. Little is known about in vivo phosphorylation of H2AX in neurons, although it was suggested th …
Phosphorylation of the histone H2AX (gammaH2AX form) is an early response to DNA damage and a marker of aging and disease in several cells a …
Development of a VLP-Based Vaccine Displaying an xCT Extracellular Domain for the Treatment of Metastatic Breast Cancer.
Rolih V, Caldeira J, Bolli E, Salameh A, Conti L, Barutello G, Riccardo F, Magri J, Lamolinara A, Parra K, Valenzuela P, Francia G, Iezzi M, Pericle F, Cavallo F. Rolih V, et al. Cancers (Basel). 2020 Jun 8;12(6):1492. doi: 10.3390/cancers12061492. Cancers (Basel). 2020. PMID: 32521631 Free PMC article.
In this paper we generated a virus-like particle (VLP)-based vaccine (AX09) to inhibit de novo metastasis formation and ultimately prolong the survival of patients with MBC. ...This antibody-based response resulted in the inhibition of xCT's function in vitro and reduced m …
In this paper we generated a virus-like particle (VLP)-based vaccine (AX09) to inhibit de novo metastasis formation and ultimately pr …
A novel bimodal approach for treating atrophic bone non-unions with extracorporeal shockwaves and autologous mesenchymal stem cell transplant.
Sansone V, Brañes M, Romeo P. Sansone V, et al. Med Hypotheses. 2018 Feb;111:4-7. doi: 10.1016/j.mehy.2017.12.013. Epub 2017 Dec 9. Med Hypotheses. 2018. PMID: 29406993
In addition to the conventional physical stimulus achieved by delivering SWs at the site of non-union to stimulate the well-known trophic effects on bone tissue, a series of concomitant ESWT would be administered in tandem at a bone marrow donor site, such as the iliac crest, to …
In addition to the conventional physical stimulus achieved by delivering SWs at the site of non-union to stimulate the well-known trophic ef …
12 results