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A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer.
Nat Cancer. 2023 Sep;4(9):1326-1344. doi: 10.1038/s43018-023-00614-y. Epub 2023 Aug 28.
Nat Cancer. 2023.
PMID: 37640930
Free PMC article.
Targeting Lysyl Oxidase Family Meditated Matrix Cross-Linking as an Anti-Stromal Therapy in Solid Tumours.
Setargew YFI, Wyllie K, Grant RD, Chitty JL, Cox TR.
Setargew YFI, et al. Among authors: grant rd.
Cancers (Basel). 2021 Jan 27;13(3):491. doi: 10.3390/cancers13030491.
Cancers (Basel). 2021.
PMID: 33513979
Free PMC article.
Review.
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The Mini-Organo: A rapid high-throughput 3D coculture organotypic assay for oncology screening and drug development.
Chitty JL, Skhinas JN, Filipe EC, Wang S, Cupello CR, Grant RD, Yam M, Papanicolaou M, Major G, Zaratzian A, Da Silva AM, Tayao M, Vennin C, Timpson P, Madsen CD, Cox TR.
Chitty JL, et al. Among authors: grant rd.
Cancer Rep (Hoboken). 2020 Feb;3(1):e1209. doi: 10.1002/cnr2.1209. Epub 2019 Aug 1.
Cancer Rep (Hoboken). 2020.
PMID: 32671954
Free PMC article.
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