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Page 1
Delivery Approaches for Therapeutic Genome Editing and Challenges.
Genes (Basel). 2020 Sep 23;11(10):1113. doi: 10.3390/genes11101113.
Genes (Basel). 2020.
PMID: 32977396
Free PMC article.
Review.
Treating hemoglobinopathies using gene-correction approaches: promises and challenges.
Cottle RN, Lee CM, Bao G.
Cottle RN, et al.
Hum Genet. 2016 Sep;135(9):993-1010. doi: 10.1007/s00439-016-1696-0. Epub 2016 Jun 17.
Hum Genet. 2016.
PMID: 27314256
Free PMC article.
Review.
Item in Clipboard
Nuclease-Mediated Gene Therapies for Inherited Metabolic Diseases of the Liver.
Bryson TE, Anglin CM, Bridges PH, Cottle RN.
Bryson TE, et al. Among authors: cottle rn.
Yale J Biol Med. 2017 Dec 19;90(4):553-566. eCollection 2017 Dec.
Yale J Biol Med. 2017.
PMID: 29259521
Free PMC article.
Review.
Item in Clipboard
In vitro Studies of Transendothelial Migration for Biological and Drug Discovery.
Salminen AT, Allahyari Z, Gholizadeh S, McCloskey MC, Ajalik R, Cottle RN, Gaborski TR, McGrath JL.
Salminen AT, et al. Among authors: cottle rn.
Front Med Technol. 2020 Nov 16;2:600616. doi: 10.3389/fmedt.2020.600616. eCollection 2020.
Front Med Technol. 2020.
PMID: 35047883
Free PMC article.
Review.
Item in Clipboard
Electroporation-mediated Delivery of Cas9 Ribonucleoproteins and mRNA into Freshly Isolated Primary Mouse Hepatocytes.
Rathbone T, Ates I, Stuart C, Parker T, Cottle RN.
Rathbone T, et al. Among authors: cottle rn.
J Vis Exp. 2022 Jun 2;(184). doi: 10.3791/63828.
J Vis Exp. 2022.
PMID: 35723482
Item in Clipboard
Electroporation-Mediated Delivery of Cas9 Ribonucleoproteins Results in High Levels of Gene Editing in Primary Hepatocytes.
Rathbone T, Ates I, Fernando L, Addlestone E, Lee CM, Richards VP, Cottle RN.
Rathbone T, et al. Among authors: cottle rn.
CRISPR J. 2022 Jun;5(3):397-409. doi: 10.1089/crispr.2021.0134. Epub 2022 Mar 2.
CRISPR J. 2022.
PMID: 35238624
Free PMC article.
Item in Clipboard
Controlled delivery of β-globin-targeting TALENs and CRISPR/Cas9 into mammalian cells for genome editing using microinjection.
Cottle RN, Lee CM, Archer D, Bao G.
Cottle RN, et al.
Sci Rep. 2015 Nov 12;5:16031. doi: 10.1038/srep16031.
Sci Rep. 2015.
PMID: 26558999
Free PMC article.
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