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Synthesis and Characterization of a New Class of Chromene-Azo Sulfonamide Hybrids as Promising Anticancer Candidates with the Exploration of Their EGFR, hCAII, and MMP-2 Inhibitors Based on Molecular Docking Assays.
Alblewi FF, Alsehli MH, Hritani ZM, Eskandrani A, Alsaedi WH, Alawad MO, Elhenawy AA, Ahmed HY, El-Gaby MSA, Afifi TH, Okasha RM. Alblewi FF, et al. Among authors: okasha rm. Int J Mol Sci. 2023 Nov 24;24(23):16716. doi: 10.3390/ijms242316716. Int J Mol Sci. 2023. PMID: 38069037 Free PMC article.
Discovery of benzochromene derivatives first example with dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the P-glycoprotein expression levels.
Al-Harbi LM, Al-Harbi EA, Okasha RM, El-Eisawy RA, El-Nassag MAA, Mohamed HM, Fouda AM, Elhenawy AA, Mora A, El-Agrody AM, El-Mawgoud HKA. Al-Harbi LM, et al. Among authors: okasha rm. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2155814. doi: 10.1080/14756366.2022.2155814. J Enzyme Inhib Med Chem. 2023. PMID: 36662632 Free PMC article.
A proficient microwave synthesis with structure elucidation and the exploitation of the biological behavior of the newly halogenated 3-amino-1H-benzo[f]chromene molecules, targeting dual inhibition of topoisomerase II and microtubules.
Fouda AM, Okasha RM, Alblewi FF, Mora A, Afifi TH, El-Agrody AM. Fouda AM, et al. Among authors: okasha rm. Bioorg Chem. 2020 Jan;95:103549. doi: 10.1016/j.bioorg.2019.103549. Epub 2019 Dec 23. Bioorg Chem. 2020. PMID: 31887476
20 results