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Page 1
Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3.
Commun Biol. 2022 Apr 13;5(1):354. doi: 10.1038/s42003-022-03311-1.
Commun Biol. 2022.
PMID: 35418200
Free PMC article.
Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer.
Ibrahim AIM, Batlle E, Sneha S, Jiménez R, Pequerul R, Parés X, Rüngeler T, Jha V, Tuccinardi T, Sadiq M, Frame F, Maitland NJ, Farrés J, Pors K.
Ibrahim AIM, et al. Among authors: pequerul r.
J Med Chem. 2022 Mar 10;65(5):3833-3848. doi: 10.1021/acs.jmedchem.1c01367. Epub 2022 Feb 25.
J Med Chem. 2022.
PMID: 35212533
Free PMC article.
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Synthesis of C11-to-C14 methyl-shifted all-trans-retinal analogues and their activities on human aldo-keto reductases.
Rivas A, Pequerul R, Barracco V, Domínguez M, López S, Jiménez R, Parés X, Alvarez R, Farrés J, de Lera AR.
Rivas A, et al. Among authors: pequerul r.
Org Biomol Chem. 2020 Jul 1;18(25):4788-4801. doi: 10.1039/d0ob01084g.
Org Biomol Chem. 2020.
PMID: 32530010
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Design, Synthesis, Biological Evaluation and In Silico Study of Benzyloxybenzaldehyde Derivatives as Selective ALDH1A3 Inhibitors.
Ibrahim AIM, Ikhmais B, Batlle E, AbuHarb WK, Jha V, Jaradat KT, Jiménez R, Pequerul R, Parés X, Farrés J, Pors K.
Ibrahim AIM, et al. Among authors: pequerul r.
Molecules. 2021 Sep 23;26(19):5770. doi: 10.3390/molecules26195770.
Molecules. 2021.
PMID: 34641313
Free PMC article.
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Structural and kinetic features of aldehyde dehydrogenase 1A (ALDH1A) subfamily members, cancer stem cell markers active in retinoic acid biosynthesis.
Pequerul R, Vera J, Giménez-Dejoz J, Crespo I, Coines J, Porté S, Rovira C, Parés X, Farrés J.
Pequerul R, et al.
Arch Biochem Biophys. 2020 Mar 15;681:108256. doi: 10.1016/j.abb.2020.108256. Epub 2020 Jan 7.
Arch Biochem Biophys. 2020.
PMID: 31923393
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Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents: Kinetic characterization and effect on human cancer cells.
Jiménez R, Pequerul R, Amor A, Lorenzo J, Metwally K, Avilés FX, Parés X, Farrés J.
Jiménez R, et al. Among authors: pequerul r.
Chem Biol Interact. 2019 Jun 1;306:123-130. doi: 10.1016/j.cbi.2019.04.004. Epub 2019 Apr 5.
Chem Biol Interact. 2019.
PMID: 30958995
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