Basement membrane stiffness determines metastases formation.
Reuten R, Zendehroud S, Nicolau M, Fleischhauer L, Laitala A, Kiderlen S, Nikodemus D, Wullkopf L, Nielsen SR, McNeilly S, Prein C, Rafaeva M, Schoof EM, Furtwängler B, Porse BT, Kim H, Won KJ, Sudhop S, Zornhagen KW, Suhr F, Maniati E, Pearce OMT, Koch M, Oddershede LB, Van Agtmael T, Madsen CD, Mayorca-Guiliani AE, Bloch W, Netz RR, Clausen-Schaumann H, Erler JT.
Reuten R, et al.
Nat Mater. 2021 Jun;20(6):892-903. doi: 10.1038/s41563-020-00894-0. Epub 2021 Jan 25.
Nat Mater. 2021.
PMID: 33495631
The basement membrane (BM) is a special type of extracellular matrix and presents the major barrier cancer cells have to overcome multiple times to form metastases. ...Mechanistically, our biophysical and functional analyses in combination with mathematical simulations sho …
The basement membrane (BM) is a special type of extracellular matrix and presents the major barrier cancer cells have to overcome mul …