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Stroke genetics informs drug discovery and risk prediction across ancestries.
Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, He Y, Georgakis MK, Caro I, Krebs K, Liaw YC, Vaura FC, Lin K, Winsvold BS, Srinivasasainagendra V, Parodi L, Bae HJ, Chauhan G, Chong MR, Tomppo L, Akinyemi R, Roshchupkin GV, Habib N, Jee YH, Thomassen JQ, Abedi V, Cárcel-Márquez J, Nygaard M, Leonard HL, Yang C, Yonova-Doing E, Knol MJ, Lewis AJ, Judy RL, Ago T, Amouyel P, Armstrong ND, Bakker MK, Bartz TM, Bennett DA, Bis JC, Bordes C, Børte S, Cain A, Ridker PM, Cho K, Chen Z, Cruchaga C, Cole JW, de Jager PL, de Cid R, Endres M, Ferreira LE, Geerlings MI, Gasca NC, Gudnason V, Hata J, He J, Heath AK, Ho YL, Havulinna AS, Hopewell JC, Hyacinth HI, Inouye M, Jacob MA, Jeon CE, Jern C, Kamouchi M, Keene KL, Kitazono T, Kittner SJ, Konuma T, Kumar A, Lacaze P, Launer LJ, Lee KJ, Lepik K, Li J, Li L, Manichaikul A, Markus HS, Marston NA, Meitinger T, Mitchell BD, Montellano FA, Morisaki T, Mosley TH, Nalls MA, Nordestgaard BG, O'Donnell MJ, Okada Y, Onland-Moret NC, Ovbiagele B, Peters A, Psaty BM, Rich SS, Rosand J, Sabatine MS, Sacco RL, Saleheen D, Sandset EC, Salomaa V, Sargurupremraj M, Sasaki M, Satizabal CL, Schmidt CO, Sh… See abstract for full author list ➔ Mishra A, et al. Nature. 2022 Nov;611(7934):115-123. doi: 10.1038/s41586-022-05165-3. Epub 2022 Sep 30. Nature. 2022. PMID: 36180795 Free PMC article.
On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < …
On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and …
A multinational Delphi consensus to end the COVID-19 public health threat.
Lazarus JV, Romero D, Kopka CJ, Karim SA, Abu-Raddad LJ, Almeida G, Baptista-Leite R, Barocas JA, Barreto ML, Bar-Yam Y, Bassat Q, Batista C, Bazilian M, Chiou ST, Del Rio C, Dore GJ, Gao GF, Gostin LO, Hellard M, Jimenez JL, Kang G, Lee N, Matičič M, McKee M, Nsanzimana S, Oliu-Barton M, Pradelski B, Pyzik O, Rabin K, Raina S, Rashid SF, Rathe M, Saenz R, Singh S, Trock-Hempler M, Villapol S, Yap P, Binagwaho A, Kamarulzaman A, El-Mohandes A; COVID-19 Consensus Statement Panel. Lazarus JV, et al. Nature. 2022 Nov;611(7935):332-345. doi: 10.1038/s41586-022-05398-2. Epub 2022 Nov 3. Nature. 2022. PMID: 36329272 Free PMC article.
Association of Fibrinogen With Ischemic Stroke: A Systematic Review and Meta-Analysis.
Prasad MK, Marandi S, Mishra B, Guria RT, Kumar A, Birua H, Ray HN, Dungdung A, Kumar D, Maitra S. Prasad MK, et al. Cureus. 2023 Jan 29;15(1):e34335. doi: 10.7759/cureus.34335. eCollection 2023 Jan. Cureus. 2023. PMID: 36721710 Free PMC article. Review.
Under the recessive model, an elevated level of serum fibrinogen is linked to an increased risk of ischemic stroke as shown by pooled odds ratio (OR: 1.47, 95% CI: 1.19-1.76, I(2) = 78.3%, P = 0.000). Our meta-analysis concluded that a high level of fibrinogen is associate …
Under the recessive model, an elevated level of serum fibrinogen is linked to an increased risk of ischemic stroke as shown by pooled odds r …
Relationship of Methylenetetrahydrofolate Reductase (MTHFR) C677T Variation With Susceptibility of Patients With Ischemic Stroke: A Meta-Analysis.
Kumar P, Mishra A, Prasad MK, Verma V, Kumar A. Kumar P, et al. Cureus. 2022 Aug 20;14(8):e28218. doi: 10.7759/cureus.28218. eCollection 2022 Aug. Cureus. 2022. PMID: 36017481 Free PMC article. Review.

Under the recessive model, a gene polymorphism at the 677 location of the MTHFR gene is related to an elevated risk of ischemic stroke (OR: 1.29, 95% CI: 1.22-1.37, P < 0.001). People who have the MTHFR C677T gene polymorphism have a greater risk of stroke than people w

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Under the recessive model, a gene polymorphism at the 677 location of the MTHFR gene is related to an elevated risk of ischemic stroke (OR: …
High fibroin-loaded silk-PCL electrospun fiber with core-shell morphology promotes epithelialization with accelerated wound healing.
Rajasekaran R, Dutta A, Ray PG, Seesala VS, Ojha AK, Dogra N, Roy S, Banerjee M, Dhara S. Rajasekaran R, et al. J Mater Chem B. 2022 Nov 30;10(46):9622-9638. doi: 10.1039/d2tb01890j. J Mater Chem B. 2022. PMID: 36366984
A comparative study of the physicomechanical properties of electrospun fibers with emulsion ((e)S(7)P(3)) and homogenous blend ((b)S(7)P(3)) was performed as well. ...Further, (e)S(7)P(3) nanostructure morphology containing silk in the core with a thin outer …
A comparative study of the physicomechanical properties of electrospun fibers with emulsion ((e)S(7)P(3)) and homogenous blend ((b)S( …
Real-life comparison of three intravitreal antibiotic drug regimens in endophthalmitis.
Bari A, Chawla R, Mishra D, Das U, Hasan N, Satpathy G, Velpandian T, Azad SV, Venkatesh P, Vohra R, Kumar A. Bari A, et al. Indian J Ophthalmol. 2022 May;70(5):1696-1700. doi: 10.4103/ijo.IJO_2640_21. Indian J Ophthalmol. 2022. PMID: 35502054 Free PMC article.
In post-surgical cases, visual recovery was poorer in those presenting beyond 72 h of onset of symptoms (P = 0.0002). Polymerase chain reaction (PCR) positivity (66%) was higher than BACTEC(TM) (33%) and culture (14%). ...
In post-surgical cases, visual recovery was poorer in those presenting beyond 72 h of onset of symptoms (P = 0.0002). Polymerase chai …
Antibiotic prophylaxis for cataract surgery - Practice patterns amongst Indian Ophthalmologists.
Kelkar AS, Sharma N, Verma L, Chandorkar SA, Saxena R, Mishra D, Kelkar JA, Sengupta S. Kelkar AS, et al. Indian J Ophthalmol. 2023 Sep;71(9):3235-3241. doi: 10.4103/IJO.IJO_702_23. Indian J Ophthalmol. 2023. PMID: 37602614 Free PMC article.
Surgeons with >10 years' experience especially practicing in medical colleges used fewer ICAB (OR = 0.52, 95%CI = 0.38 - 0.72, P < 0,001) compared to younger surgeons (<5-year experience) in solo clinics. ...
Surgeons with >10 years' experience especially practicing in medical colleges used fewer ICAB (OR = 0.52, 95%CI = 0.38 - 0.72, P & …
Use of Paravertebral Block as an Alternative to General Anesthesia for Breast Surgeries: A Randomized Control Study.
Mishra N, Haque E, Bhagat M, Kumar V, Suwalka U, Gorai P. Mishra N, et al. Cureus. 2021 Sep 27;13(9):e18322. doi: 10.7759/cureus.18322. eCollection 2021 Sep. Cureus. 2021. PMID: 34722086 Free PMC article.
RESULTS: Duration of surgery in group P was 64.7518.07 and 67.3217.64 in group G respectively (P>0.05). Time for inducing anaesthesia was significantly longer in group P (17.153.92min) compared to group G (5.901.75min) with P<0.05. ...
RESULTS: Duration of surgery in group P was 64.7518.07 and 67.3217.64 in group G respectively (P>0.05). Time for inducing a …
Seroprevalence of chikungunya virus infection in India, 2017: a cross-sectional population-based serosurvey.
Kumar MS, Kamaraj P, Khan SA, Allam RR, Barde PV, Dwibedi B, Kanungo S, Mohan U, Mohanty SS, Roy S, Sagar V, Savargaonkar D, Tandale BV, Topno RK, Kumar CPG, Sabarinathan R, Kumar VS, Bitragunta S, Grover GS, Lakshmi PVM, Mishra CM, Sadhukhan P, Sahoo PK, Singh SK, Yadav CP, Dinesh ER, Karunakaran T, Govindhasamy C, Rajasekar TD, Jeyakumar A, Suresh A, Augustine D, Kumar PA, Kumar R, Dutta S, Toteja GS, Gupta N, Clapham HE, Mehendale SM, Murhekar MV. Kumar MS, et al. Lancet Microbe. 2021 Jan;2(1):e41-e47. doi: 10.1016/S2666-5247(20)30175-0. Lancet Microbe. 2021. PMID: 35544228 Free article.
There was a significant difference in seroprevalence between rural (11.5% [8.8-15.0]) and urban (40.2% [31.7-49.3]) areas (p<0.0001). The seroprevalence did not differ by sex (male 18.8% [95% CI 15.2-23.0] vs female 17.6% [13.2-23.1]; p=0.50). ...
There was a significant difference in seroprevalence between rural (11.5% [8.8-15.0]) and urban (40.2% [31.7-49.3]) areas (p<0.000 …
Proteo-Molecular Investigation of Cultivated Rice, Wild Rice, and Barley Provides Clues of Defense Responses against Rhizoctonia solani Infection.
Shamim M, Sharma D, Bisht D, Maurya R, Kaashyap M, Srivastava D, Mishra A, Kumar D, Kumar M, Juturu VN, Khan NA, Chaudhary S, Hussain R, Singh KN. Shamim M, et al. Bioengineering (Basel). 2022 Oct 20;9(10):589. doi: 10.3390/bioengineering9100589. Bioengineering (Basel). 2022. PMID: 36290557 Free PMC article.
28 results