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Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo.
Siska PJ, Jiao J, Matos C, Singer K, Berger RS, Dettmer K, Oefner PJ, Cully MD, Wang Z, QuinnIII WJ, Oliff KN, Wilkins BJ, Christensen LM, Wang L, Hancock WW, Baur JA, Levine MH, Ugele I, Mayr R, Renner K, Zhou L, Kreutz M, Beier UH. Siska PJ, et al. Among authors: berger rs. EBioMedicine. 2021 Dec;74:103734. doi: 10.1016/j.ebiom.2021.103734. Epub 2021 Dec 4. EBioMedicine. 2021. PMID: 34875457 Free PMC article.
D-2-hydroxyglutarate supports a tolerogenic phenotype with lowered major histocompatibility class II expression in non-malignant dendritic cells and acute myeloid leukemia cells.
Hammon K, Renner K, Althammer M, Voll F, Babl N, Decking SM, Siska PJ, Matos C, Conejo ZEC, Mendes K, Einwag F, Siegmund H, Iberl S, Berger RS, Dettmer K, Schoenmehl R, Brochhausen C, Herr W, Oefner PJ, Rehli M, Thomas S, Kreutz M. Hammon K, et al. Among authors: berger rs. Haematologica. 2024 Jan 18. doi: 10.3324/haematol.2023.283597. Online ahead of print. Haematologica. 2024. PMID: 38235501 Free article.