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Antidepressant drugs act by directly binding to TRKB neurotrophin receptors.
Casarotto PC, Girych M, Fred SM, Kovaleva V, Moliner R, Enkavi G, Biojone C, Cannarozzo C, Sahu MP, Kaurinkoski K, Brunello CA, Steinzeig A, Winkel F, Patil S, Vestring S, Serchov T, Diniz CRAF, Laukkanen L, Cardon I, Antila H, Rog T, Piepponen TP, Bramham CR, Normann C, Lauri SE, Saarma M, Vattulainen I, Castrén E. Casarotto PC, et al. Among authors: moliner r. Cell. 2021 Mar 4;184(5):1299-1313.e19. doi: 10.1016/j.cell.2021.01.034. Epub 2021 Feb 18. Cell. 2021. PMID: 33606976 Free PMC article.
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB.
Moliner R, Girych M, Brunello CA, Kovaleva V, Biojone C, Enkavi G, Antenucci L, Kot EF, Goncharuk SA, Kaurinkoski K, Kuutti M, Fred SM, Elsilä LV, Sakson S, Cannarozzo C, Diniz CRAF, Seiffert N, Rubiolo A, Haapaniemi H, Meshi E, Nagaeva E, Öhman T, Róg T, Kankuri E, Vilar M, Varjosalo M, Korpi ER, Permi P, Mineev KS, Saarma M, Vattulainen I, Casarotto PC, Castrén E. Moliner R, et al. Nat Neurosci. 2023 Jun;26(6):1032-1041. doi: 10.1038/s41593-023-01316-5. Epub 2023 Jun 5. Nat Neurosci. 2023. PMID: 37280397 Free PMC article.
Perineuronal Net Receptor PTPσ Regulates Retention of Memories.
Lesnikova A, Casarotto P, Moliner R, Fred SM, Biojone C, Castrén E. Lesnikova A, et al. Among authors: moliner r. Front Synaptic Neurosci. 2021 Jul 22;13:672475. doi: 10.3389/fnsyn.2021.672475. eCollection 2021. Front Synaptic Neurosci. 2021. PMID: 34366821 Free PMC article.
Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2.
Fred SM, Laukkanen L, Brunello CA, Vesa L, Göös H, Cardon I, Moliner R, Maritzen T, Varjosalo M, Casarotto PC, Castrén E. Fred SM, et al. Among authors: moliner r. J Biol Chem. 2019 Nov 29;294(48):18150-18161. doi: 10.1074/jbc.RA119.008837. Epub 2019 Oct 20. J Biol Chem. 2019. PMID: 31631060 Free PMC article.
N-Doped Carbon Xerogels as Pt Support for the Electro-Reduction of Oxygen.
Alegre C, Sebastián D, Gálvez ME, Baquedano E, Moliner R, Aricò AS, Baglio V, Lázaro MJ. Alegre C, et al. Among authors: moliner r. Materials (Basel). 2017 Sep 17;10(9):1092. doi: 10.3390/ma10091092. Materials (Basel). 2017. PMID: 28926984 Free PMC article.