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Are the current commercially available oximes capable of reactivating acetylcholinesterase inhibited by the nerve agents of the A-series?
Santos MC, Botelho FD, Gonçalves AS, Kitagawa DAS, Borges CVN, Carvalho-Silva T, Bernardo LB, Ferreira CN, Rodrigues RB, Ferreira Neto DC, Nepovimova E, Kuča K, LaPlante SR, Lima ALS, França TCC, Cavalcante SFA. Santos MC, et al. Among authors: rodrigues rb. Arch Toxicol. 2022 Sep;96(9):2559-2572. doi: 10.1007/s00204-022-03316-z. Epub 2022 Jun 6. Arch Toxicol. 2022. PMID: 35666269
In Vitro Evaluation of Neutral Aryloximes as Reactivators for Electrophorus eel Acetylcholinesterase Inhibited by Paraoxon.
Kitagawa DAS, Cavalcante SFA, de Paula RL, Rodrigues RB, Bernardo LB, da Silva MCJ, da Silva TN, Dos Santos WV, Granjeiro JM, de Almeida JSFD, Barcellos MC, de A Correa AB, França TCC, Kuča K, Simas ABC. Kitagawa DAS, et al. Among authors: rodrigues rb. Biomolecules. 2019 Oct 8;9(10):583. doi: 10.3390/biom9100583. Biomolecules. 2019. PMID: 31597234 Free PMC article.
Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators.
Kitagawa DAS, Rodrigues RB, Silva TN, Dos Santos WV, da Rocha VCV, de Almeida JSFD, Bernardo LB, Carvalho-Silva T, Ferreira CN, da Silva AAT, Simas ABC, Nepovimova E, Kuča K, França TCC, Cavalcante SFA. Kitagawa DAS, et al. Among authors: rodrigues rb. J Enzyme Inhib Med Chem. 2021 Dec;36(1):1370-1377. doi: 10.1080/14756366.2021.1916009. J Enzyme Inhib Med Chem. 2021. PMID: 34148470 Free PMC article.
Synthesis and in vitro evaluation of neutral aryloximes as reactivators of Electrophorus eel acetylcholinesterase inhibited by NEMP, a VX surrogate.
Cavalcante SFA, Kitagawa DAS, Rodrigues RB, Bernardo LB, da Silva TN, Dos Santos WV, Correa ABA, de Almeida JSFD, França TCC, Kuča K, Simas ABC. Cavalcante SFA, et al. Among authors: rodrigues rb. Chem Biol Interact. 2019 Aug 25;309:108682. doi: 10.1016/j.cbi.2019.05.048. Epub 2019 Jun 1. Chem Biol Interact. 2019. PMID: 31163137