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Asymmetric dimethyl arginine induces pulmonary vascular dysfunction via activation of signal transducer and activator of transcription 3 and stabilization of hypoxia-inducible factor 1-alpha.
Pekarova M, Koudelka A, Kolarova H, Ambrozova G, Klinke A, Cerna A, Kadlec J, Trundova M, Sindlerova Svihalkova L, Kuchta R, Kuchtova Z, Lojek A, Kubala L. Pekarova M, et al. Among authors: kuchta r. Vascul Pharmacol. 2015 Oct;73:138-48. doi: 10.1016/j.vph.2015.06.005. Epub 2015 Jun 17. Vascul Pharmacol. 2015. PMID: 26091577
Asymmetric dimethylarginine regulates the lipopolysaccharide-induced nitric oxide production in macrophages by suppressing the activation of NF-kappaB and iNOS expression.
Pekarova M, Kubala L, Martiskova H, Bino L, Twarogova M, Klinke A, Rudolph TK, Kuchtova Z, Kolarova H, Ambrozova G, Kuchta R, Kadlec J, Lojek A. Pekarova M, et al. Among authors: kuchta r. Eur J Pharmacol. 2013 Aug 5;713(1-3):68-77. doi: 10.1016/j.ejphar.2013.05.001. Epub 2013 May 9. Eur J Pharmacol. 2013. PMID: 23665490