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Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons.
Bogetofte H, Ryan BJ, Jensen P, Schmidt SI, Vergoossen DLE, Barnkob MB, Kiani LN, Chughtai U, Heon-Roberts R, Caiazza MC, McGuinness W, Márquez-Gómez R, Vowles J, Bunn FS, Brandes J, Kilfeather P, Connor JP, Fernandes HJR, Caffrey TM, Meyer M, Cowley SA, Larsen MR, Wade-Martins R. Bogetofte H, et al. Among authors: heon roberts r. Cell Rep. 2023 Mar 28;42(3):112180. doi: 10.1016/j.celrep.2023.112180. Epub 2023 Mar 3. Cell Rep. 2023. PMID: 36870058 Free article.
Mitochondrial dysfunction and mitophagy defects in LRRK2-R1441C Parkinson's disease models.
Williamson MG, Madureira M, McGuinness W, Heon-Roberts R, Mock ED, Naidoo K, Cramb KML, Caiazza MC, Malpartida AB, Lavelle M, Savory K, Humble SW, Patterson R, Davis JB, Connor-Robson N, Ryan BJ, Wade-Martins R. Williamson MG, et al. Among authors: heon roberts r. Hum Mol Genet. 2023 Sep 5;32(18):2808-2821. doi: 10.1093/hmg/ddad102. Hum Mol Genet. 2023. PMID: 37384414 Free PMC article.
CRISPRi: a way to integrate iPSC-derived neuronal models.
Franks SNJ, Heon-Roberts R, Ryan BJ. Franks SNJ, et al. Among authors: heon roberts r. Biochem Soc Trans. 2024 Apr 24;52(2):539-551. doi: 10.1042/BST20230190. Biochem Soc Trans. 2024. PMID: 38526223 Review.
Selective Inhibitors of Human Neuraminidase 1 (NEU1).
Guo T, Héon-Roberts R, Zou C, Zheng R, Pshezhetsky AV, Cairo CW. Guo T, et al. Among authors: heon roberts r. J Med Chem. 2018 Dec 27;61(24):11261-11279. doi: 10.1021/acs.jmedchem.8b01411. Epub 2018 Dec 5. J Med Chem. 2018. PMID: 30457869
Identification of bioactive metabolites in human iPSC-derived dopaminergic neurons with PARK2 mutation: Altered mitochondrial and energy metabolism.
Okarmus J, Havelund JF, Ryding M, Schmidt SI, Bogetofte H, Heon-Roberts R, Wade-Martins R, Cowley SA, Ryan BJ, Færgeman NJ, Hyttel P, Meyer M. Okarmus J, et al. Among authors: heon roberts r. Stem Cell Reports. 2021 Jun 8;16(6):1510-1526. doi: 10.1016/j.stemcr.2021.04.022. Epub 2021 May 27. Stem Cell Reports. 2021. PMID: 34048689 Free PMC article.