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Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment.
Abdul-Aziz AM, Sun Y, Hellmich C, Marlein CR, Mistry J, Forde E, Piddock RE, Shafat MS, Morfakis A, Mehta T, Di Palma F, Macaulay I, Ingham CJ, Haestier A, Collins A, Campisi J, Bowles KM, Rushworth SA. Abdul-Aziz AM, et al. Among authors: piddock re. Blood. 2019 Jan 31;133(5):446-456. doi: 10.1182/blood-2018-04-845420. Epub 2018 Nov 6. Blood. 2019. PMID: 30401703 Free PMC article.
Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment.
Shafat MS, Oellerich T, Mohr S, Robinson SD, Edwards DR, Marlein CR, Piddock RE, Fenech M, Zaitseva L, Abdul-Aziz A, Turner J, Watkins JA, Lawes M, Bowles KM, Rushworth SA. Shafat MS, et al. Among authors: piddock re. Blood. 2017 Mar 9;129(10):1320-1332. doi: 10.1182/blood-2016-08-734798. Epub 2017 Jan 3. Blood. 2017. PMID: 28049638 Free article.