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The marine compound and elongation factor 1A1 inhibitor, didemnin B, provides benefit in western diet-induced non-alcoholic fatty liver disease.
Wilson RB, Chen YJ, Sutherland BG, Sawyez CG, Zhang R, Woolnough T, Hetherington AM, Peters KM, Patel K, Kennelly JP, Leonard KA, Schuurman M, Jacobs RL, Wang R, Borradaile NM. Wilson RB, et al. Pharmacol Res. 2020 Nov;161:105208. doi: 10.1016/j.phrs.2020.105208. Epub 2020 Sep 22. Pharmacol Res. 2020. PMID: 32977024 Free article.
Elongation factor 1A1 regulates metabolic substrate preference in mammalian cells.
Wilson RB, Kozlov AM, Hatam Tehrani H, Twumasi-Ankrah JS, Chen YJ, Borrelli MJ, Sawyez CG, Maini S, Shepherd TG, Cumming RC, Betts DH, Borradaile NM. Wilson RB, et al. J Biol Chem. 2024 Mar;300(3):105684. doi: 10.1016/j.jbc.2024.105684. Epub 2024 Jan 23. J Biol Chem. 2024. PMID: 38272231 Free PMC article.